3-chloro-4-hydroxyphenylacetic acid ethyl ester

Base Information

• Chemical Name: 3-chloro-4-hydroxyphenylacetic acid ethyl ester
• CAS No.: 193357-36-7
• Molecular Formula: C₁₀H₁₁ClO₃
• Molecular Weight: 214.649
• Mol file: 193357-36-7.mol

Synonyms:3-chloro-4-hydroxyphenylacetic acid ethyl ester

Chemical Property of 3-chloro-4-hydroxyphenylacetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-chloro-4-hydroxyphenylacetic acid ethyl ester

There total 5 articles about 3-chloro-4-hydroxyphenylacetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

ethanol (64-17-5) + (3-chloro-4-hydroxy-phenyl)-acetic acid (33697-81-3) → 3-chloro-4-hydroxyphenylacetic acid ethyl ester (193357-36-7)

Guidance literature:

With thionyl chloride; at 20 ℃; for 48h;

DOI:10.1021/jm061202u

Reference yield: 90.0%

ethyl 3-chloro-4-methoxyphenylacetate (39923-59-6) → 3-chloro-4-hydroxyphenylacetic acid ethyl ester (193357-36-7)

Guidance literature:

With boron tribromide; In dichloromethane; at -78 ℃; for 1.5h;

Reference yield: 82.0%

(3-chloro-4-hydroxy-phenyl)-acetic acid (33697-81-3) + ethyl iodide (75-03-6) → 3-chloro-4-hydroxyphenylacetic acid ethyl ester (193357-36-7)

Guidance literature:

With cesium fluoride; In acetonitrile; for 6h; Heating;

DOI:10.1080/00397919808007177

upstream raw materials:

(3-chloro-4-hydroxy-phenyl)-acetic acid

ethyl iodide

ethanol

ethyl 3-chloro-4-methoxyphenylacetate

Downstream raw materials:

ethyl {4-[3,3-bis-(4-bromo-phenyl)-allyloxy]-3-chloro-phenyl}-acetate

ethyl 2-(3-bromo-5-chloro-4-(2,2,2-trifluoroethoxy)phenyl)acetate

ethyl 2-(3-bromo-5-chloro-4-hydroxyphenyl)acetate

2-(3-(benzo[c][1,2,5]thiadiazol-5-yl)-5-chloro-4-(cyclopropylmethoxy)phenyl)-4-methylpentanoic acid

Refernces

• 1、 -. "TETRASUBSTITUTED BENZENES FOR TREATMENT OF EARLY ONSET ALZHEIMER'S DISEASE". Paragraph 0450; 0451. . Retrieved 2013/07/25.
• 2、 -. "TETRASUBSTITUTED BENZENES". Page/Page column 187. . Retrieved 2009/08/14.