4,6-DIBROMO ISATIN

Base Information

• Chemical Name: 4,6-DIBROMO ISATIN
• CAS No.: 187326-67-6
• Molecular Formula: C8H3 Br2 N O2
• Molecular Weight: 304.925
• Hs Code.: 2933990090
• Mol file: 187326-67-6.mol

Synonyms:4,6-Dibromoisatin

Chemical Property of 4,6-DIBROMO ISATIN

Chemical Property:

• Refractive Index: 1.678
• PSA: 46.17000
• Density: 2.179g/cm³
• LogP: 2.48440
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

4,6-Dibromoindoline-2,3-dione 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,6-DIBROMO ISATIN

There total 11 articles about 4,6-DIBROMO ISATIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4,6-dibromoindole (99910-50-6) → 4,6-dibromoindoline-2,3-dione (187326-67-6)

Guidance literature:

With oxygen; Rose Bengal lactone; In water; N,N-dimethyl-formamide; for 48h; Inert atmosphere; Irradiation;

DOI:10.1002/chem.201904168

Reference yield: 86.0%

N-(3,5-dibromophenyl)-2-(hydroxyimino)acetamide → 4,6-dibromoindoline-2,3-dione (187326-67-6)

Guidance literature:

With sulfuric acid; at 60 - 110 ℃;

DOI:10.1016/S0040-4039(97)00140-8

Reference yield: 85.0%

3,5-dibromoisonitrosoacetanilide (187326-66-5) → 4,6-dibromoindoline-2,3-dione (187326-67-6)

Guidance literature:

With sulfuric acid; for 0.0111111h; microwave irradiation;

DOI:10.1080/00397919908085998

upstream raw materials:

3,5-dibromoisonitrosoacetanilide

5-nitroisatin

indole-2,3-dione

5-amino-5',5'-dimethylspiro[indoline-3,2'-[1,3]dioxan]-2-one

Downstream raw materials:

C₁₇H₁₁Br₂F₂NO₃

C₁₇H₁₁Br₂F₂NO₄

(R)-4,6-dibromo-3-hydroxy-3-(2-oxo-2-phenylethyl)indolin-2-one

C₁₅H₉Br₂NO₂

Refernces

• 1、 Seong, Churl Min,Park, Woo Kyu,Park, Chul Min,Kong, Jae Yang,Park, No Sang. "Discovery of 3-aryl-3-methyl-1H-quinoline-2,4-diones as a new class of selective 5-HT6 receptor antagonists". . p. 738 - 743. Retrieved 2008/12/23.
• 2、 Jnaneshwar,Deshpande. "Synthesis of convolutamydine a from isatin". . p. 632 - 633. Retrieved 2007/10/03.