Technology Process of N-benzyl-4-methyl-2-(2-oxoimidazolidin-1-yl)thiazole-5-carboxamide
There total 3 articles about N-benzyl-4-methyl-2-(2-oxoimidazolidin-1-yl)thiazole-5-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-chloroethyl isothiocyanate; 2-amino-4-methylthiazole-5-carboxylic acid benzylamide;
With
N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran;
at 20 ℃;
for 48h;
With
tetra-(n-butyl)ammonium iodide; potassium carbonate;
In
1,4-dioxane;
for 24h;
Heating / reflux;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydroxide; water / tetrahydrofuran / 18 h / Heating / reflux
1.2: pH 5 - 6
2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h
2.2: 48 h / 20 °C
3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 48 h / 20 °C
3.2: 24 h / Heating / reflux
With
sodium hydroxide; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h
1.2: 48 h / 20 °C
2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 48 h / 20 °C
2.2: 24 h / Heating / reflux
With
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; N,N-dimethyl-formamide;