clarithromycin dibenzoate

Base Information

• Chemical Name: clarithromycin dibenzoate
• CAS No.: 484670-64-6
• Molecular Formula: C₅₂H₇₇NO₁₅
• Molecular Weight: 956.181
• Mol file: 484670-64-6.mol

Synonyms:clarithromycin dibenzoate

Chemical Property of clarithromycin dibenzoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of clarithromycin dibenzoate

There total 9 articles about clarithromycin dibenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

clarithromycin (81103-11-9) + benzoic acid anhydride (93-97-0) → clarithromycin dibenzoate (484670-64-6)

Guidance literature:

With 2-(dimethylamino)pyrimidine; triethylamine; In N,N-dimethyl-formamide; at 45 ℃; for 4h;

DOI:10.1021/jm051157a

Reference yield: 95.0%

C56H86N2O16 → clarithromycin dibenzoate (484670-64-6)

Guidance literature:

With sodium metabisulfite; formic acid; for 6h; Temperature; Reflux;

Reference yield:

2',4''-dibenzoyl-O-(2-methoxy-2-propyl)erythromycin A 9-oxime (1349852-75-0) + methyl iodide (74-88-4) → clarithromycin dibenzoate + clarithromycin dibenzoate (484670-64-6)

Guidance literature:

2',4''-dibenzoyl-O-(2-methoxy-2-propyl)erythromycin A 9-oxime; methyl iodide; With potassium hydroxide; In tetrahydrofuran; dimethyl sulfoxide; at 0 - 20 ℃;

With sodium metabisulfite; formic acid; In ethanol; water; at 60 ℃; for 8h; pH=2 - 3;

With sodium hydrogencarbonate; In ethanol; water;

upstream raw materials:

clarithromycin

benzoic acid anhydride

2',4''-dibenzoyl-O-(2-methoxy-2-propyl)erythromycin A 9-oxime

methyl iodide

Downstream raw materials:

(3aS,4R,7S,9R,10R,11R,13R,15R)-1-(4-(4-(3-aminophenyl)-1H-1,2,3-triazol-1-yl)butyl)-10-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-4-ethyl-7-fluoro-11-methoxy-3a,7,9,11,13,15-hexamethyloctahydro-1H-[1]oxacyclotetradecino[4,3-d]oxazole-2,6,8,14(7H,9H)-tetraone

Refernces

• 1、 -. "Solithromycin and preparation method of intermediate thereof". Paragraph 0061-0062. . Retrieved 2017/04/03.
• 2、 -. "HYDROGEN BOND FORMING FLUORO KETOLIDES FOR TREATING DISEASES". Page/Page column 33-34. . Retrieved 2012/03/27.