Multi-step reaction with 8 steps
1.1: potassium carbonate / tetrakis(triphenylphosphine) palladium(0) / toluene / Inert atmosphere; Reflux
2.1: methanol / 0.5 h / 0 - 20 °C
3.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C
3.2: 96 h / 50 °C / Inert atmosphere
4.1: hydrogenchloride / ethyl acetate; water / 0.5 h / 20 °C
5.1: chloroformic acid ethyl ester; 4-methyl-morpholine / dichloromethane / 0.5 h / 0 °C
5.2: 2 h / 20 °C
6.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 3 h / 20 °C
6.2: pH 2 - 3
7.1: chloroformic acid ethyl ester; 4-methyl-morpholine / dichloromethane / 0.5 h / 0 °C
7.2: 20 °C
8.1: 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl-formamide / 3 h / 20 °C
With
4-methyl-morpholine; hydrogenchloride; n-butyllithium; 1,3,5-trichloro-2,4,6-triazine; lithium hydroxide monohydrate; water; chloroformic acid ethyl ester; potassium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene;