N-benzyl-O-benzoylhydroxylamine

Base Information

• Chemical Name: N-benzyl-O-benzoylhydroxylamine
• CAS No.: 38636-02-1
• Molecular Formula: C₁₄H₁₃NO₂
• Molecular Weight: 227.263
• Mol file: 38636-02-1.mol

Synonyms:N-benzyl-O-benzoylhydroxylamine

Chemical Property of N-benzyl-O-benzoylhydroxylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyl-O-benzoylhydroxylamine

There total 7 articles about N-benzyl-O-benzoylhydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-benzylhydroxylamine hydrochloride (29601-98-7) + benzoic acid (65-85-0,8013-63-6) → N-benzyl-O-benzoylhydroxylamine (38636-02-1)

Guidance literature:

benzoic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; for 0.25h;

N-benzylhydroxylamine hydrochloride; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/ja401150m

Reference yield: 63.0%

benzylamine (100-46-9) + dibenzoyl peroxide (94-36-0) → N-benzyl-O-benzoylhydroxylamine (38636-02-1)

Guidance literature:

With pH 10.5 buffer; In dichloromethane; Ambient temperature;

DOI:10.1021/jo981613l

Reference yield:

N-Benzylidenebenzylamine N-oxide (3376-26-9) + benzoyl chloride (98-88-4) → N-benzyl-O-benzoylhydroxylamine (38636-02-1) + N-benzylbenzamide (1485-70-7) + N,O-dibenzoyl-N-benzylhydroxylamine (19172-64-6)

Guidance literature:

In dichloromethane; at 20 ℃; for 0.0519444h; Flow reactor;

DOI:10.1055/s-0039-1691601

upstream raw materials:

benzylamine

dibenzoyl peroxide

diethyl ether

N-Benzylidenebenzylamine N-oxide

Downstream raw materials:

N-benzyl hydroxylalmine

benzoic acid

benzyl nitrate

benzoic acid benzyl ester

Refernces

• 1、 Arakawa, Yukihiro,Imada, Yasushi,Minagawa, Keiji,Okamoto, Takuma,Ueta, Shun. "Nucleophilic Addition to Nitrones Using a Flow Microreactor". supporting information. p. 866 - 870. Retrieved 2020/05/28.
• 2、 Niu, Dawen,Buchwald, Stephen L.. "Design of modified amine transfer reagents allows the synthesis of α-chiral secondary amines via CuH-catalyzed hydroamination". . p. 9716 - 9721. Retrieved 2015/08/18.