1-{1-(cyclohexylmethyl)-5-[difluoro(phenyl)methoxy]-1H-pyrazol-3-yl}-N-methylmethanamine hydrochloride

Base Information

• Chemical Name: 1-{1-(cyclohexylmethyl)-5-[difluoro(phenyl)methoxy]-1H-pyrazol-3-yl}-N-methylmethanamine hydrochloride
• CAS No.: 1355352-68-9
• Molecular Formula: C₁₉H₂₅F₂N₃O*ClH
• Molecular Weight: 385.885
• Mol file: 1355352-68-9.mol

Synonyms:1-{1-(cyclohexylmethyl)-5-[difluoro(phenyl)methoxy]-1H-pyrazol-3-yl}-N-methylmethanamine hydrochloride

Chemical Property of 1-{1-(cyclohexylmethyl)-5-[difluoro(phenyl)methoxy]-1H-pyrazol-3-yl}-N-methylmethanamine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-{1-(cyclohexylmethyl)-5-[difluoro(phenyl)methoxy]-1H-pyrazol-3-yl}-N-methylmethanamine hydrochloride

There total 2 articles about 1-{1-(cyclohexylmethyl)-5-[difluoro(phenyl)methoxy]-1H-pyrazol-3-yl}-N-methylmethanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

C24H33F2N3O3 (1355356-19-2) → 1-{1-(cyclohexylmethyl)-5-[difluoro(phenyl)methoxy]-1H-pyrazol-3-yl}-N-methylmethanamine hydrochloride (1355352-68-9)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; chloroform; at 20 ℃; for 0.5h;

Reference yield:

tert-butyl {[1-(cyclohexylmethyl)-5-oxo-4,5-dihydro-1H-pyrazol-3-yl]-methyl}methylcarbamate (1355355-15-5) + a-bromo-a,a-difluorotoluene (83170-17-6) → 1-{1-(cyclohexylmethyl)-5-[difluoro(phenyl)methoxy]-1H-pyrazol-3-yl}-N-methylmethanamine hydrochloride (1355352-68-9)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate / acetonitrile / 24 h / 50 °C

2: hydrogenchloride / chloroform; 1,4-dioxane / 0.5 h / 20 °C

With hydrogenchloride; caesium carbonate; In 1,4-dioxane; chloroform; acetonitrile;

upstream raw materials:

tert-butyl {[1-(cyclohexylmethyl)-5-oxo-4,5-dihydro-1H-pyrazol-3-yl]-methyl}methylcarbamate

a-bromo-a,a-difluorotoluene

C₂₄H₃₃F₂N₃O₃

Refernces