2-Chloro-6-iodopyridin-3-ol

Base Information

• Chemical Name: 2-Chloro-6-iodopyridin-3-ol
• CAS No.: 185220-68-2
• Molecular Formula: C5H3 Cl I N O
• Molecular Weight: 255.442
• Hs Code.: 2933399090
• European Community (EC) Number: 683-597-6
• DSSTox Substance ID: DTXSID60444800
• Wikidata: Q82263071
• Mol file: 185220-68-2.mol

Synonyms:2-Chloro-6-iodopyridin-3-ol;185220-68-2;2-chloro-6-iodo-3-pyridinol;2-Chloro-3-hydroxy-6-iodopyridine;2-chloro-6-iodo-pyridin-3-ol;3-Pyridinol, 2-chloro-6-iodo-;MFCD10566651;3-Pyridinol,2-chloro-6-iodo-;2-chloro-3-hydroxy-6-iodo-pyridine;SCHEMBL315024;AMY7773;DTXSID60444800;WQSIHSWWVYQVPV-UHFFFAOYSA-N;2-chloro-3-hydroxy-6-iodo-pyridin;GEO-03679;VT1246;AKOS005072435;ED-0052;SB12722;AC-27539;SY029607;2-Chloro-3-hydroxy-6-iodopyridine, 97%;CS-0036964;FT-0680968;EN300-184116;A880730;J-508943

Chemical Property of 2-Chloro-6-iodopyridin-3-ol

Chemical Property:

• Melting Point: 141-145°C
• Boiling Point: 394.5±42.0 °C(Predicted)
• PKA: 3.96±0.10(Predicted)
• PSA: 33.12000
• Density: 2.219±0.06 g/cm3(Predicted)
• LogP: 2.04520
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 254.89479
• Heavy Atom Count: 9
• Complexity: 103

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Chloro-6-iodopyridin-3-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC(=NC(=C1O)Cl)I

Technology Process of 2-Chloro-6-iodopyridin-3-ol

There total 2 articles about 2-Chloro-6-iodopyridin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2-chloro-3-hydroxypyridine (6636-78-8) → 2-chloro-3-hydroxy-6-iodo-pyridine (185220-68-2)

Guidance literature:

With iodine; sodium carbonate; In water; at 20 ℃; for 2h;

DOI:10.1021/jo402200q

Reference yield:

2-chloro-3-hydroxypyridine (6636-78-8) + chloroamine-T (127-65-1) → 2-chloro-3-hydroxy-6-iodo-pyridine (185220-68-2)

Guidance literature:

With hydrogenchloride; sodium iodide; In N-methyl-acetamide;

Reference yield: 99.0%

benzyl bromide (100-39-0) + 2-chloro-3-hydroxy-6-iodo-pyridine (185220-68-2) → 3-(benzyloxy)-2-chloro-6-iodopyridine (185221-60-7)

Guidance literature:

2-chloro-3-hydroxy-6-iodo-pyridine; With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 0.5h;

benzyl bromide; In dimethyl sulfoxide; for 2h;

DOI:10.1021/ol501967c

upstream raw materials:

2-chloro-3-hydroxypyridine

chloroamine-T

Downstream raw materials:

4-chloro-benzenesulfonic acid 2-chloro-4,6-diiodo-pyridin-3-yl ester

(3R,αS)-tert-butyl 3-(2-chloro-3-methoxymethoxy-6-pyridyl)-3-(N-α-methyl-4-methoxybenzylamino)propanoate

(R)-3-[Benzyl-((S)-1-phenyl-ethyl)-amino]-3-(6-chloro-5-methoxymethoxy-pyridin-2-yl)-propionic acid tert-butyl ester

2-Chloro-3-[(2,6-dichlorophenyl)methoxy]-6-iodopyridine

Refernces

• 1、 Lin, Wenwei,Chen, Ling,Knochel, Paul. "Preparation of functionalized 3,4-pyridynes via 2-magnesiated diaryl sulfonates". . p. 2787 - 2797. Retrieved 2007/10/03.
• 2、 -. "Nitrogen-containing aromatic derivatives". . . Retrieved 2008/06/13.