methyl 4-oxo-1-phenyl-3-phosphorinanecarboxylate

Base Information

• Chemical Name: methyl 4-oxo-1-phenyl-3-phosphorinanecarboxylate
• CAS No.: 63316-04-1
• Molecular Formula: C₁₃H₁₅O₃P
• Molecular Weight: 250.234
• Mol file: 63316-04-1.mol

Synonyms:methyl 4-oxo-1-phenyl-3-phosphorinanecarboxylate

Chemical Property of methyl 4-oxo-1-phenyl-3-phosphorinanecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 4-oxo-1-phenyl-3-phosphorinanecarboxylate

There total 1 articles about methyl 4-oxo-1-phenyl-3-phosphorinanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bis(2-(carbomethoxy)ethyl)phenylphosphine (6775-11-7) → methyl 4-oxo-1-phenyl-3-phosphorinanecarboxylate (63316-04-1)

Guidance literature:

Multistep reaction; (i) NaOMe, MeOH, toluene, (ii) aq. HCl;

DOI:10.1007/BF00946866

Reference yield: 53.0%

methyl 4-oxo-1-phenyl-3-phosphorinanecarboxylate (63316-04-1) → methyl 4-oxo-1-phenyl-3-phosphorinanecarboxylate 1-oxide (67976-13-0)

Guidance literature:

With dihydrogen peroxide; In acetone; at 0 ℃; for 0.166667h;

DOI:10.1021/ja00398a025

Reference yield:

methyl 4-oxo-1-phenyl-3-phosphorinanecarboxylate (63316-04-1) → 1,2,3,4-tetrahydro-10-hydroxy-8-methyl-3-phenyl-5H-phosphorino<3,4-c><1>benzopyran-5-one 3-oxide (77217-77-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 53 percent / 30percent H₂O₂ / acetone / 0.17 h / 0 °C

2: 1.) conc. H₂SO₄, 2.) Cl₃P=O / 1.) 5 min, 2.) room temperature, 40 h

With sulfuric acid; dihydrogen peroxide; trichlorophosphate; In acetone;

DOI:10.1021/ja00398a025

upstream raw materials:

bis(2-(carbomethoxy)ethyl)phenylphosphine

Downstream raw materials:

4-oxo-1-phenyl-1-thioxo-1λ⁵-phosphinane-3-carboxylic acid methyl ester

1-phenyl-4-phosphorinanone

methyl 4-oxo-1-phenyl-3-phosphorinanecarboxylate 1-oxide

4-oxo-1-phenyl-1-selenoxo-1λ⁵-phosphinane-3-carboxylic acid methyl ester

Refernces