Ciproxifan maleate

Base Information

• Chemical Name: Ciproxifan maleate
• CAS No.: 184025-19-2
• Molecular Formula: C16H18N2O2.C4H4O4
• Molecular Weight: 386.402
• European Community (EC) Number: 634-051-0
• ChEMBL ID: CHEMBL128672
• DSSTox Substance ID: DTXSID20585107
• Mol file: 184025-19-2.mol

Synonyms:Ciproxifan maleate;184025-19-2;Ciproxifan (maleate);FUB 359 maleate salt;FUB 359 maleate;(4-(3-(1H-imidazol-5-yl)propoxy)phenyl)(cyclopropyl)methanone maleate;MFCD06411563;Ciproxifan maleate(FUB-359 maleate);(Z)-but-2-enedioic acid;cyclopropyl-[4-[3-(1H-imidazol-5-yl)propoxy]phenyl]methanone;Cyclopropyl (4-[3-(1H-imidazol-4-yl)propyloxy]phenyl) ketone maleate salt;Ciproxifanmaleate;CHEMBL128672;DTXSID20585107;EX-A942;TCMDC-143632;HMS3884F18;s2813;AKOS027250765;AKOS037515493;BCP9000706;CCG-268479;CS-0924;AC-32889;AS-62098;HY-15289;BCP0726000034;Ciproxifan maleate, >=98% (HPLC), powder;SW219167-1;Z2312424809;(4-(3-(1H-Imidazol-4-yl)propoxy)phenyl)(cyclopropyl)methanone maleate;(2Z)-but-2-enedioic acid;4-[3-(4-cyclopropanecarbonylphenoxy)propyl]-1H-imidazole;(2Z)-But-2-enedioic acid--cyclopropyl{4-[3-(1H-imidazol-5-yl)propoxy]phenyl}methanone (1/1);(4-(3-(1H-imidazol-4-yl)propyl1H-imidazol-4-yl)propoxy)phenyl)(cyclopropyl)methanone maleate

Chemical Property of Ciproxifan maleate

Chemical Property:

• Vapor Pressure: 3.22E-23mmHg at 25°C
• Boiling Point: 743.6°C at 760 mmHg
• Flash Point: 403.5°C
• PSA: 129.58000
• LogP: 2.72580
• Solubility.: DMSO: soluble32mg/mL
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 9
• Exact Mass: 386.14778643
• Heavy Atom Count: 28
• Complexity: 441

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ciproxifan maleate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-36/37/38-43
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CC1C(=O)C2=CC=C(C=C2)OCCCC3=CN=CN3.C(=CC(=O)O)C(=O)O
• Isomeric SMILES: C1CC1C(=O)C2=CC=C(C=C2)OCCCC3=CN=CN3.C(=C\C(=O)O)\C(=O)O
• Description: Ciproxifan is a histamine H3 receptor antagonist (Ki = 0.5 nM for inhibition of histamine release in rat synaptosomal preparations). It is selective for histamine H3 over histamine H1 and H2, M3 muscarinic, and α1D- and β1-adrenergic receptors (Kis = 3.15-25 μM), as well as the serotonin (5-HT) receptor subtypes 5-HT1B, 5-HT2A, 5-HT3, and 5-HT4 (Kis = 1.58-15 μM) in radioligand binding assays. Ciproxifan (3-300 nM) inhibits relaxation in precontracted isolated guinea pig ileal longitudinal muscle induced by R-(–)-α-methylhistamine . In vivo, ciproxifan reduces R-(–)-α-methylhistamine-induced water consumption in rats (ED50 = 0.09 mg/kg). It increases wake episode duration and latency to fall asleep in rats when administered at a dose of 2 mg/kg.
• Uses: Ciproxifan is a potent histamine H3 receptor antagonist which affects histamine levels in the brain. It may be used in treatments for sleep and neurological disorders.