2-Bromo-4-pyridine acetic acid

Base Information

• Chemical Name: 2-Bromo-4-pyridine acetic acid
• CAS No.: 183483-29-6
• Molecular Formula: C₇H₆BrNO₂
• Molecular Weight: 216.034
• Hs Code.: 2933399090
• Mol file: 183483-29-6.mol

Synonyms:4-Pyridineacetic acid, 2-bromo-;

Chemical Property of 2-Bromo-4-pyridine acetic acid

Chemical Property:

• Vapor Pressure: 2.93E-06mmHg at 25°C
• Melting Point: 145-150°C
• Refractive Index: 1.599
• Boiling Point: 374.1 °C at 760 mmHg
• PKA: 3.66±0.10(Predicted)
• Flash Point: 180 °C
• PSA: 50.19000
• Density: 1.71 g/cm³
• LogP: 1.47120
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Bromopyridine-4-acetic acid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-4-pyridine acetic acid

There total 3 articles about 2-Bromo-4-pyridine acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl 2-(2-bromo-4-pyridyl)acetate (1256337-24-2) → 2-(2-bromopyridin-4-yl)acetic acid (183483-29-6)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 0.166667h;

Reference yield:

diethyl 2-(2-bromopyridin-4-yl)malonate (1387560-71-5) → 2-(2-bromopyridin-4-yl)acetic acid (183483-29-6)

Guidance literature:

With water; potassium carbonate; at 100 ℃; for 8h;

Reference yield:

2-Bromo-4-picoline (4926-28-7) → 2-(2-bromopyridin-4-yl)acetic acid (183483-29-6)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium diisopropyl amide / toluene; tetrahydrofuran; ethylbenzene / 2 h / -78 °C

2: potassium carbonate; water / 8 h / 100 °C

With water; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; ethylbenzene; toluene;

upstream raw materials:

2-Bromo-4-picoline

diethyl 2-(2-bromopyridin-4-yl)malonate

ethyl 2-(2-bromo-4-pyridyl)acetate

Downstream raw materials:

methyl 2-(2-bromopyridin-4-yl)acetate

ethyl 2-(2-bromo-4-pyridyl)acetate

Refernces

• 1、 -. "Novel Heterocyclic Derivatives and Their Use in the Treatment of Neurological Disorders". . . Retrieved 2012/07/28.