Technology Process of 4′-((1R,2S)-2-(2-amino-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)cyclopropyl)biphenyl-3-carboxamide hydrochloride
There total 6 articles about 4′-((1R,2S)-2-(2-amino-1-methyl-6-oxo-1,6-dihydropyrimidin-4-yl)cyclopropyl)biphenyl-3-carboxamide hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide; 2-bis(tert-butoxycarbonyl)amino-3-methyl-6-[(1S,2R)-2-(3-bromophenyl)cyclopropyl]pyrimidin-4(3H)-one;
With
dichlorobis(triphenylphosphine)palladium; potassium carbonate;
In
1,4-dioxane; water;
at 150 ℃;
Microwave irradiation;
With
hydrogenchloride;
In
1,4-dioxane;
DOI:10.1021/jm3011405
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C
2.1: dmap / dichloromethane / 20 °C / Inert atmosphere
3.1: water; potassium hydroxide / ethanol / 60 °C
4.1: N,O-bis-(trimethylsilyl)-acetamide / 0.5 h / 20 °C / Inert atmosphere
4.2: 1 h / 20 °C
5.1: 2,2'-azobis(isobutyronitrile); tributylphosphine; (2-pyridyl-N-Oxide) sulfide; tri-n-butyl-tin hydride / toluene / 20 - 80 °C / Inert atmosphere
6.1: dichlorobis(triphenylphosphine)palladium; potassium carbonate / 1,4-dioxane; water / 150 °C / Microwave irradiation
With
dmap; N,O-bis-(trimethylsilyl)-acetamide; 2,2'-azobis(isobutyronitrile); tributylphosphine; dichlorobis(triphenylphosphine)palladium; (2-pyridyl-N-Oxide) sulfide; water; tri-n-butyl-tin hydride; potassium carbonate; potassium hydroxide;
In
1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
5.1: |Barton Decarboxylation / 6.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm3011405
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N,O-bis-(trimethylsilyl)-acetamide / 0.5 h / 20 °C / Inert atmosphere
1.2: 1 h / 20 °C
2.1: 2,2'-azobis(isobutyronitrile); tributylphosphine; (2-pyridyl-N-Oxide) sulfide; tri-n-butyl-tin hydride / toluene / 20 - 80 °C / Inert atmosphere
3.1: dichlorobis(triphenylphosphine)palladium; potassium carbonate / 1,4-dioxane; water / 150 °C / Microwave irradiation
With
N,O-bis-(trimethylsilyl)-acetamide; 2,2'-azobis(isobutyronitrile); tributylphosphine; dichlorobis(triphenylphosphine)palladium; (2-pyridyl-N-Oxide) sulfide; tri-n-butyl-tin hydride; potassium carbonate;
In
1,4-dioxane; water; toluene;
2.1: |Barton Decarboxylation / 3.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm3011405
