Technology Process of R-(+)-6,6'-BIS(DIPHENYLPHOSPHINO)-2,2',3,3'-TETRAHYDRO-5,5'-BI-1,4-BENZODIOXIN
There total 6 articles about R-(+)-6,6'-BIS(DIPHENYLPHOSPHINO)-2,2',3,3'-TETRAHYDRO-5,5'-BI-1,4-BENZODIOXIN which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 100 percent / NBS / dimethylformamide / 24 h / 20 °C
2.1: n-BuLi / tetrahydrofuran; hexane / 1.17 h / -78 °C
2.2: tetrahydrofuran; hexane / -70 - 0 °C
3.1: aq. H2O2 / methanol / 1 h / 20 °C
4.1: t-BuLi / pentane; tetrahydrofuran / 3.5 h / -100 - -70 °C
4.2: I2 / pentane; tetrahydrofuran / 2 h / -70 - 0 °C
5.1: Cu / dimethylformamide / 4 h / 140 °C
6.1: (+)-O,O-dibenzoyltartaric acid / CH2Cl2
6.2: aq. CH2Cl2 / CH2Cl2 / 0.5 h
7.1: 91 percent / NBu3; HSiCl3 / xylene / 140 °C
With
N-Bromosuccinimide; n-butyllithium; (+)-dibenzoyl-D-tartaricacid; tributyl-amine; trichlorosilane; dihydrogen peroxide; tert.-butyl lithium; copper;
In
tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; xylene; pentane;
5.1: Ullmann reaction / 6.1: resolution of racemate;
DOI:10.1002/ejoc.200200634
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: n-BuLi / tetrahydrofuran; hexane / 1.17 h / -78 °C
1.2: tetrahydrofuran; hexane / -70 - 0 °C
2.1: aq. H2O2 / methanol / 1 h / 20 °C
3.1: t-BuLi / pentane; tetrahydrofuran / 3.5 h / -100 - -70 °C
3.2: I2 / pentane; tetrahydrofuran / 2 h / -70 - 0 °C
4.1: Cu / dimethylformamide / 4 h / 140 °C
5.1: (+)-O,O-dibenzoyltartaric acid / CH2Cl2
5.2: aq. CH2Cl2 / CH2Cl2 / 0.5 h
6.1: 91 percent / NBu3; HSiCl3 / xylene / 140 °C
With
n-butyllithium; (+)-dibenzoyl-D-tartaricacid; tributyl-amine; trichlorosilane; dihydrogen peroxide; tert.-butyl lithium; copper;
In
tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; xylene; pentane;
4.1: Ullmann reaction / 5.1: resolution of racemate;
DOI:10.1002/ejoc.200200634