Technology Process of D-myo-Inositol, 1-O-(4-methoxyphenyl)methyl-2,6-bis-O-(phenylmethyl)-, trisbis(phenylmethyl) phosphate
There total 12 articles about D-myo-Inositol, 1-O-(4-methoxyphenyl)methyl-2,6-bis-O-(phenylmethyl)-, trisbis(phenylmethyl) phosphate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Dibenzyl N,N-diisopropylphosphoramidite;
With
1H-tetrazole;
In
dichloromethane;
at 23 ℃;
for 0.5h;
(-)-2,6-di-O-benzyl-1-O-(p-methoxybenzyl)-myo-inositol;
In
dichloromethane;
at 23 ℃;
for 12h;
With
3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
at -40 ℃;
for 0.5h;
DOI:10.1021/jo960602u
- Guidance literature:
-
With
3-chloro-benzenecarboperoxoic acid;
In
dichloromethane; acetonitrile;
at 0 ℃;
for 2h;
Yield given;
DOI:10.1016/S0008-6215(96)00211-X
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: di-n-butyltin oxide / toluene / 2 h / Heating
1.2: 96 percent / CsF / dimethylformamide / 17 h / -15 - 20 °C
2.1: NaH / dimethylformamide / 0.5 h / 0 °C
2.2: 98 percent / dimethylformamide / 40 °C
3.1: 82 percent / p-toluenesulfonic acid; water / Pd/C / methanol / 2 h / Heating
4.1: 1H-tetrazole / CH2Cl2 / 0.5 h / 23 °C
4.2: CH2Cl2 / 12 h / 23 °C
4.3: 95 percent / m-chloroperoxybenzoic acid / CH2Cl2 / 0.5 h / -40 °C
With
1H-tetrazole; water; sodium hydride; di(n-butyl)tin oxide; toluene-4-sulfonic acid;
palladium on activated charcoal;
In
methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
1.1: coordination / 1.2: Etherification / 2.1: Metallation / 2.2: Etherification / 3.1: Hydrolysis / 4.1: Addition / 4.2: phosphorylation / 4.3: Oxidation;
DOI:10.1021/jo960602u