Technology Process of (6R,7R)-3-(carbamoyloxymethyl)-7-[[(2E)-2-(furan-2-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
There total 8 articles about (6R,7R)-3-(carbamoyloxymethyl)-7-[[(2E)-2-(furan-2-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
isocyanate de chlorosulfonyle; 3-decarbamoyl cefuroxime acid;
In
ethyl acetate;
at -50 - -40 ℃;
for 0.666667h;
With
water;
In
ethyl acetate;
for 0.5h;
- Guidance literature:
-
With
hydrogenchloride; sodium ethanolate;
In
tetrahydrofuran; ethanol; water; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: phosphorus pentachloride / ethyl acetate; N,N-dimethyl acetamide / 2.5 h / 0 - 10 °C
2.1: sulfuric acid / acetone / 6 h / 50 °C
3.1: sodium hydroxide / water / 5 h / -10 - -5 °C
4.1: sodium hydroxide / acetone; water / 0.5 h / -12 - -5 °C
5.1: ethyl acetate / 0.67 h / -50 - -40 °C
5.2: 0.5 h
With
phosphorus pentachloride; sulfuric acid; sodium hydroxide;
In
N,N-dimethyl acetamide; water; ethyl acetate; acetone;
