C₂₈H₂₈N₈

Base Information Edit

Chemical Name:C₂₈H₂₈N₈
CAS No.:1228633-28-0
Molecular Formula:C₂₈H₂₈N₈
Molecular Weight:476.584
Hs Code.:
Mol file:1228633-28-0.mol

C<sub>28</sub>H<sub>28</sub>N<sub>8</sub>

Synonyms:C₂₈H₂₈N₈

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Chemical Property of C₂₈H₂₈N₈ Edit

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Technology Process of C₂₈H₂₈N₈

There total 30 articles about C₂₈H₂₈N₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1261071-90-2
C₄₄H₅₈N₈O₅Si

: 1228633-28-0
C₂₈H₂₈N₈

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; ethanol; at 75 ℃;
DOI:10.1002/cmdc.201400045

Reference yield:

: 1261071-90-2
tert-butyl (2S)-2-(5-[2-(4-{2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-imidazol-5-yl}phenyl)quinoxalin-6-yl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate

: 1228633-28-0
6-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-5-yl}-2-(4-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-5-yl}phenyl)quinoxaline

Guidance literature:: tert-butyl (2S)-2-(5-[2-(4-{2-[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]-1H-imidazol-5-yl}phenyl)quinoxalin-6-yl]-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)pyrrolidine-1-carboxylate; With hydrogenchloride; In 1,4-dioxane; ethanol; at 75 ℃; for 1.5h;

With sodium hydroxide; In water; pH=~ 11;

Reference yield:

: 1007882-58-7,1332326-40-5
(S)-tert-butyl 2-(1H-imidazol-2-yl)pyrrolidine-1-carboxylate

: 1228633-28-0
6-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-5-yl}-2-(4-{2-[(2S)-pyrrolidin-2-yl]-1H-imidazol-5-yl}phenyl)quinoxaline

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C / Inert atmosphere

1.2: 1.5 h / 20 °C

2.1: N-Bromosuccinimide / dichloromethane / 1 h / 20 °C

3.1: TurboGrignard / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

3.2: 16 h / 20 °C

4.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 5 h / 80 °C

5.1: hydrogenchloride / 1,4-dioxane; ethanol / 1.5 h / 75 °C

5.2: pH ~ 11

With hydrogenchloride; N-Bromosuccinimide; TurboGrignard; sodium hydride; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; 1,2-dimethoxyethane; ethanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;