(S)-Sulconazole

Base Information

• Chemical Name: (S)-Sulconazole
• CAS No.: 180185-78-8
• Molecular Formula: C₁₈H₁₅Cl₃N₂S
• Molecular Weight: 397.755
• Mol file: 180185-78-8.mol

Synonyms:1H-Imidazole,1-[2-[[(4-chlorophenyl)methyl]thio]-2-(2,4-dichlorophenyl)ethyl]-, (S)-;(S)-Sulconazole

Chemical Property of (S)-Sulconazole

Chemical Property:

• PSA: 43.12000
• LogP: 6.51800

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-Sulconazole

There total 19 articles about (S)-Sulconazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + Glyoxal (131543-46-9,107-22-2) + (R)-2-((4-chlorobenzyl)thio)-2-(2,4-dichlorophenyl)ethanamine (1165796-83-7) → (R)-sulconazole (180185-77-7,180185-78-8)

Guidance literature:

With ammonium acetate; In methanol; water; at 95 ℃; for 16h; Inert atmosphere;

DOI:10.1021/ja903351a

Reference yield: 72.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + Glyoxal (131543-46-9,107-22-2) + (S)-2-((4-chlorobenzyl)thio)-2-(2,4-dichlorophenyl)ethanamine → (S)-sulconazole (180185-78-8)

Guidance literature:

With ammonium acetate; In methanol; at 95 ℃; for 16h;

DOI:10.1021/acs.joc.8b01403

Reference yield:

→ sulconazole (61318-90-9,180185-78-8)

Guidance literature:

1-(2,4,β-Trichlor-phenylethyl)-imidazol + 4-Chlor-benzylmercaptan.;

upstream raw materials:

formaldehyd

Glyoxal

(R)-2-((4-chlorobenzyl)thio)-2-(2,4-dichlorophenyl)ethanamine

C₁₀H₁₁Cl₂NOS

Refernces

• 1、 Niu, Sheng-Tong,Liu, Hui,Xu, Yan-Jun,Lu, Chong-Dao. "Diastereoselective α-Sulfenylation of N- tert-Butanesulfinyl Imidates". . p. 10580 - 10588. Retrieved 2018/09/18.
• 2、 Kimmel, Kyle L.,Robak, MaryAnn T.,Ellman, Jonathan A.. "Enantioselective addition of thioacetic acid to nitroalkenes via N-sulfinyl urea organocatalysis". supporting information; experimental part. p. 8754 - 8755. Retrieved 2009/12/04.