C₃₂H₄₉N₇O₉

Base Information

• Chemical Name: C₃₂H₄₉N₇O₉
• CAS No.: 1367370-17-9
• Molecular Formula: C₃₂H₄₉N₇O₉
• Molecular Weight: 675.783
• Mol file: 1367370-17-9.mol

Synonyms:C₃₂H₄₉N₇O₉

Chemical Property of C₃₂H₄₉N₇O₉

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₂H₄₉N₇O₉

There total 8 articles about C₃₂H₄₉N₇O₉ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

4-{[(benzyloxy)carbonyl]amino}oxane-4-carboxylic acid (138402-13-8) + GlyNH2-Aib4-NH2 (1367370-59-9) → C32H49N7O9 (1367370-17-9)

Guidance literature:

4-{[(benzyloxy)carbonyl]amino}oxane-4-carboxylic acid; With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere;

GlyNH₂-Aib₄-NH₂; In dichloromethane; at 0 - 20 ℃; for 96h; Inert atmosphere;

DOI:10.1039/c2cc00060a

Reference yield:

N3(α-aminoisobutyric acid)4OtBu (1187839-02-6) → C32H49N7O9 (1367370-17-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: trifluoroacetic acid / dichloromethane / Inert atmosphere

2.1: acetic anhydride / 2 h / 120 °C / Inert atmosphere

3.1: triethylamine / acetonitrile / 72 h / Inert atmosphere

4.1: palladium on activated charcoal; hydrogen / methanol

5.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

5.2: 96 h / 0 - 20 °C / Inert atmosphere

With palladium on activated charcoal; hydrogen; acetic anhydride; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; dichloromethane; acetonitrile;

DOI:10.1039/c2cc00060a

Reference yield:

C16H26N6O4 (1187839-36-6) → C32H49N7O9 (1367370-17-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / acetonitrile / 72 h / Inert atmosphere

2.1: palladium on activated charcoal; hydrogen / methanol

3.1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

3.2: 96 h / 0 - 20 °C / Inert atmosphere

With palladium on activated charcoal; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; acetonitrile;

DOI:10.1039/c2cc00060a

upstream raw materials:

Tetrahydro-4H-pyran-4-one

8-oxa-1,3-diazaspiro[4.5]decane-2,4-dione

N₃(α-aminoisobutyric acid)₄OtBu

N₃Aib₄-OH

Downstream raw materials:

C₅₇H₈₆N₁₂O₁₄

Refernces