2-NAPHTHYL 4-PIPERIDINYL ETHER

Base Information

• Chemical Name: 2-NAPHTHYL 4-PIPERIDINYL ETHER
• CAS No.: 78055-93-3
• Molecular Formula: C₁₅H₁₇NO
• Molecular Weight: 227.306
• Mol file: 78055-93-3.mol

Synonyms:4-(2-naphthalenyloxy)piperidine

Chemical Property of 2-NAPHTHYL 4-PIPERIDINYL ETHER

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

2-Naphthyl 4-piperidinyl ether ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of 2-NAPHTHYL 4-PIPERIDINYL ETHER

There total 4 articles about 2-NAPHTHYL 4-PIPERIDINYL ETHER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(phenylmethyl)-4-(2-naphthalenyloxy)piperidine (78055-90-0) → 4-(2-naphthalenyloxy)piperidine (78055-93-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1016/S0040-4039(03)01117-1

Reference yield:

1-benzyl-4-hydroxypiperidine (4727-72-4) → 4-(2-naphthalenyloxy)piperidine (78055-93-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: polymer-supported 1,5,7-triazabicyclo[4.4.0]dec-5-ene; KI / CHCl₃ / Heating

1.2: sulfonic acid resin / CHCl₃

1.3: NH₃ / methanol

2.1: trifluoroacetic acid / CH₂Cl₂

With 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene on polystyrene.HL; trifluoroacetic acid; potassium iodide; In dichloromethane; chloroform;

DOI:10.1016/S0040-4039(03)01117-1

Reference yield:

β-naphthol (135-19-3) → 4-(2-naphthalenyloxy)piperidine (78055-93-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: polymer-supported 1,5,7-triazabicyclo[4.4.0]dec-5-ene; KI / CHCl₃ / Heating

1.2: sulfonic acid resin / CHCl₃

1.3: NH₃ / methanol

2.1: trifluoroacetic acid / CH₂Cl₂

With 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene on polystyrene.HL; trifluoroacetic acid; potassium iodide; In dichloromethane; chloroform;

DOI:10.1016/S0040-4039(03)01117-1

upstream raw materials:

1-(phenylmethyl)-4-(2-naphthalenyloxy)piperidine

1-benzyl-4-hydroxypiperidine

β-naphthol

Refernces

• 1、 -. "Antipsychotic 4-(naphthalenyloxy)piperidine derivatives". . . Retrieved 2008/06/13.