H-D-SER(TBU)-OTBU HCL

Base Information

• Chemical Name: H-D-SER(TBU)-OTBU HCL
• CAS No.: 179559-35-4
• Molecular Formula: C₁₁H₂₃NO₃*ClH
• Molecular Weight: 253.769
• Mol file: 179559-35-4.mol

Synonyms:O-T-BUTYL-D-SERINE T-BUTYL ESTER HYDROCHLORIDE;O-T-BUTYL-D-SERINE T-BUTYL ESTER HYDROCHLORIDE SALT;H-D-SER(BUT)-OBUT HCL;H-D-SER(TBU)-OTBU HCL;O-tert-Butyl-D-serine tert-butyl ester hydrochloride

Chemical Property of H-D-SER(TBU)-OTBU HCL

Chemical Property:

• PSA: 61.55000
• LogP: 2.97280
• Storage Temp.: Store at 0-5°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

H-D-Ser(tBu)-OtBuHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of H-D-SER(TBU)-OTBU HCL

There total 2 articles about H-D-SER(TBU)-OTBU HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

O-(1,1-dimethylethyl)-N-[(phenylmethoxy)carbonyl]-L-serine 1,1-dimethylethyl ester (58455-98-4) → O-tert-butyl-L-serine tert-butyl ester hydrochloride (51537-21-4,179559-35-4)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / 5percent Pd/C / methanol

2: 1 M HCl / ethyl acetate / Ambient temperature

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; ethyl acetate;

DOI:10.1021/jo00090a045

Reference yield:

N-BOC-O-tert-butylserine tert-butyl ester → O-tert-butyl-L-serine tert-butyl ester hydrochloride (51537-21-4,179559-35-4)

Guidance literature:

With hydrogenchloride; In ethyl acetate; Yield given; Ambient temperature;

DOI:10.1021/jo00090a045

Reference yield: 97.0%

O-tert-butyl-L-serine tert-butyl ester hydrochloride (51537-21-4,179559-35-4) + Z-Phe-D-Val-OH (17460-97-8) → Z-Phe-D-Val-Ser(tBu)-OtBu

Guidance literature:

O-tert-butyl-L-serine tert-butyl ester hydrochloride; Z-Phe-D-Val-OH; With ethyl acetate; ethyl cyanoglyoxylate-2-oxime; for 0.0166667h; Milling; Sealed tube;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; for 0.333333h; Milling; Sealed tube;

DOI:10.1021/acs.orglett.0c03209

upstream raw materials:

O-(1,1-dimethylethyl)-N-[(phenylmethoxy)carbonyl]-L-serine 1,1-dimethylethyl ester

Downstream raw materials:

O-tert-butyl L-serine tert-butyl ester

Refernces