3,4,5-trimethoxy-2-(3,4-methylenedioxy-6-nitrophenyl)bromomethylbenzene

Base Information

• Chemical Name: 3,4,5-trimethoxy-2-(3,4-methylenedioxy-6-nitrophenyl)bromomethylbenzene
• CAS No.: 1407590-19-5
• Molecular Formula: C₁₇H₁₆BrNO₇
• Molecular Weight: 426.221
• Mol file: 1407590-19-5.mol

Synonyms:3,4,5-trimethoxy-2-(3,4-methylenedioxy-6-nitrophenyl)bromomethylbenzene

Chemical Property of 3,4,5-trimethoxy-2-(3,4-methylenedioxy-6-nitrophenyl)bromomethylbenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,4,5-trimethoxy-2-(3,4-methylenedioxy-6-nitrophenyl)bromomethylbenzene

There total 6 articles about 3,4,5-trimethoxy-2-(3,4-methylenedioxy-6-nitrophenyl)bromomethylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

C17H17NO8 (1407590-18-4) → 3,4,5-trimethoxy-2-(3,4-methylenedioxy-6-nitrophenyl)bromomethylbenzene (1407590-19-5)

Guidance literature:

With phosphorus tribromide; In dichloromethane; at 0 - 20 ℃; for 0.75h;

DOI:10.2174/157017812802850276

Reference yield:

3,4,5-trimethoxy-benzaldehyde (86-81-7) → 3,4,5-trimethoxy-2-(3,4-methylenedioxy-6-nitrophenyl)bromomethylbenzene (1407590-19-5)

Guidance literature:

Multi-step reaction with 4 steps

1: N-Bromosuccinimide / chloroform / 3 h / Reflux

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾

3: sodium tetrahydroborate / methanol / 0.25 h / 25 °C

4: phosphorus tribromide / dichloromethane / 0.75 h / 0 - 20 °C

With sodium tetrahydroborate; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; phosphorus tribromide; In methanol; dichloromethane; chloroform; 2: |Stille Cross Coupling;

DOI:10.2174/157017812802850276

Reference yield:

2-bromo-3,4,5-tri-methoxybenzaldehyde (35274-53-4) → 3,4,5-trimethoxy-2-(3,4-methylenedioxy-6-nitrophenyl)bromomethylbenzene (1407590-19-5)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾

2: sodium tetrahydroborate / methanol / 0.25 h / 25 °C

3: phosphorus tribromide / dichloromethane / 0.75 h / 0 - 20 °C

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; phosphorus tribromide; In methanol; dichloromethane; 1: |Stille Cross Coupling;

DOI:10.2174/157017812802850276

upstream raw materials:

C₁₇H₁₇NO₈

1,2-(methylenedioxy)-4-bromobenzene

1-bromo-4,5-methylenedioxy-2-nitrobenzene

3,4,5-trimethoxy-benzaldehyde

Refernces