Technology Process of 1,6,17,29-tetrakis(benzyloxy)-7,10,18,21-tetraoxo-6,11,17,22,28-pentaazaoctacosane
There total 16 articles about 1,6,17,29-tetrakis(benzyloxy)-7,10,18,21-tetraoxo-6,11,17,22,28-pentaazaoctacosane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
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284666-57-5
28-(tert-butoxycarbonyl)-1,6,17,29-tetrakis(benzyloxy)-7,10,18,21-tetraoxo-6,11,17,22,28-pentaazaoctacosane
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284666-64-4
1,6,17,29-tetrakis(benzyloxy)-7,10,18,21-tetraoxo-6,11,17,22,28-pentaazaoctacosane
- Guidance literature:
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With
sodium hydrogencarbonate; trifluoroacetic acid;
In
dichloromethane;
Inert atmosphere;
DOI:10.1021/ol301869x
DOI:10.1021/ol301869x
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284666-64-4
1,6,17,29-tetrakis(benzyloxy)-7,10,18,21-tetraoxo-6,11,17,22,28-pentaazaoctacosane
- Guidance literature:
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With
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
dichloromethane;
for 7h;
DOI:10.1021/jo000050m
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284666-64-4
1,6,17,29-tetrakis(benzyloxy)-7,10,18,21-tetraoxo-6,11,17,22,28-pentaazaoctacosane
- Guidance literature:
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Multi-step reaction with 7 steps
1: 98 percent / NaH; NaI / dimethylformamide
2: 91 percent / H2; NH3 / Raney Ni / methanol
3: 91 percent / DPPA; Et3N / acetonitrile / 0 - 20 °C
4: 99 percent / TFA / CH2Cl2 / 0.25 h / 20 °C
5: 73 percent / DNAP / pyridine / 20 - 95 °C
6: 94 percent / DPPA; Et3N / acetonitrile / 0 - 20 °C
7: 76 percent / TFA / CH2Cl2 / 0.33 h
With
diphenyl-phosphinic acid; ammonia; hydrogen; sodium hydride; triethylamine; trifluoroacetic acid; sodium iodide;
nickel;
In
pyridine; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
1: Substitution / 2: Catalytic hydrogenation / 3: Acylation / 4: Hydrolysis / 5: Acylation / 6: Acylation / 7: Hydrolysis;
DOI:10.1021/jo000050m