Technology Process of cis-methyl 1-(benzoylamino)-1-(pentamethylenecarbamoyl)cyclobutane-3-carboxylate
There total 9 articles about cis-methyl 1-(benzoylamino)-1-(pentamethylenecarbamoyl)cyclobutane-3-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: H2 / Pd/C / ethyl acetate / 20 h / 760 Torr
2: 96 percent / Heating
3: Et3N / 1 h / 0 - 20 °C
4: 1.) BuLi / 1.) THF, -40 deg C - -50 deg C, 1 h, 2.) THF, -50 deg C, - RT
5: 0.4 g / sodium amalgam / tetrahydrofuran; methanol / 3 h / Ambient temperature
6: tetrahydrofuran; diethyl ether
With
sodium amalgam; n-butyllithium; hydrogen; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; ethyl acetate;
DOI:10.1021/jm00051a005
- Guidance literature:
-
Multi-step reaction with 7 steps
1: CH2Cl2 / 1 h / Ambient temperature
2: H2 / Pd/C / ethyl acetate / 20 h / 760 Torr
3: 96 percent / Heating
4: Et3N / 1 h / 0 - 20 °C
5: 1.) BuLi / 1.) THF, -40 deg C - -50 deg C, 1 h, 2.) THF, -50 deg C, - RT
6: 0.4 g / sodium amalgam / tetrahydrofuran; methanol / 3 h / Ambient temperature
7: tetrahydrofuran; diethyl ether
With
sodium amalgam; n-butyllithium; hydrogen; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; ethyl acetate;
DOI:10.1021/jm00051a005
- Guidance literature:
-
Multi-step reaction with 8 steps
1: SOCl2 / 1 h / 75 °C
2: CH2Cl2 / 1 h / Ambient temperature
3: H2 / Pd/C / ethyl acetate / 20 h / 760 Torr
4: 96 percent / Heating
5: Et3N / 1 h / 0 - 20 °C
6: 1.) BuLi / 1.) THF, -40 deg C - -50 deg C, 1 h, 2.) THF, -50 deg C, - RT
7: 0.4 g / sodium amalgam / tetrahydrofuran; methanol / 3 h / Ambient temperature
8: tetrahydrofuran; diethyl ether
With
sodium amalgam; n-butyllithium; thionyl chloride; hydrogen; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; ethyl acetate;
DOI:10.1021/jm00051a005