1,4-bis((4-butylphenyl)ethynyl)-2-ethylbenzene

Base Information

• Chemical Name: 1,4-bis((4-butylphenyl)ethynyl)-2-ethylbenzene
• CAS No.: 1373161-59-1
• Molecular Formula: C₃₂H₃₄
• Molecular Weight: 418.622
• Mol file: 1373161-59-1.mol

Synonyms:1,4-bis((4-butylphenyl)ethynyl)-2-ethylbenzene

Chemical Property of 1,4-bis((4-butylphenyl)ethynyl)-2-ethylbenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,4-bis((4-butylphenyl)ethynyl)-2-ethylbenzene

There total 3 articles about 1,4-bis((4-butylphenyl)ethynyl)-2-ethylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

2-ethyl-1,4-diiodobenzene (89976-52-3) + (4-butylphenyl)acetylene (79887-09-5) → 1,4-bis((4-butylphenyl)ethynyl)-2-ethylbenzene (1373161-59-1)

Guidance literature:

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In tetrahydrofuran; at 20 ℃; for 3h; Inert atmosphere; Reflux;

Reference yield:

2-ethyl-4-iodo-phenylamine (99471-67-7) → 1,4-bis((4-butylphenyl)ethynyl)-2-ethylbenzene (1373161-59-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium nitrite; hydrogenchloride / water

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / Inert atmosphere; Reflux

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium nitrite; In tetrahydrofuran; water; 2: |Sonogashira Cross-Coupling;

DOI:10.1039/c5ra15291g

Reference yield:

ortho-ethylaniline (578-54-1) → 1,4-bis((4-butylphenyl)ethynyl)-2-ethylbenzene (1373161-59-1)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydrogencarbonate; iodine / dichloromethane

2: sodium nitrite; hydrogenchloride / water

3: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / Inert atmosphere; Reflux

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; iodine; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium nitrite; In tetrahydrofuran; dichloromethane; water; 3: |Sonogashira Cross-Coupling;

DOI:10.1039/c5ra15291g

upstream raw materials:

2-ethyl-1,4-diiodobenzene

(4-butylphenyl)acetylene

2-ethyl-4-iodo-phenylamine

ortho-ethylaniline

Refernces

• 1、 -. "LIQUID CRYSTAL COMPOUND FOR HIGH-FREQUENCY APPARATUS AND LIQUID CRYSTAL COMPOSITION". Paragraph 0132-0133. . Retrieved 2021/06/21.