Technology Process of N-[3-(1-benzyl-1H-indol-3-yl)-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]methansulfonamide
There total 7 articles about N-[3-(1-benzyl-1H-indol-3-yl)-1,1-dioxido-4H-1,2,4-benzothiadiazin-7-yl]methansulfonamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: trichlorophosphate / Cooling with ice
1.2: 2 h / 10 - 35 °C
1.3: Cooling with ice; Reflux
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C
2.2: 2 h
3.1: sodium hydrogensulfite / N,N-dimethyl acetamide / 2 h / 150 °C
With
sodium hydride; sodium hydrogensulfite; trichlorophosphate;
In
N,N-dimethyl acetamide; N,N-dimethyl-formamide; mineral oil;
1.1: Vilsmeier-Haack reaction / 1.2: Vilsmeier-Haack reaction;
DOI:10.1016/j.bmc.2012.01.031
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C
1.2: 2 h
2.1: sodium hydrogensulfite / N,N-dimethyl acetamide / 2 h / 150 °C
With
sodium hydride; sodium hydrogensulfite;
In
N,N-dimethyl acetamide; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2012.01.031
