Technology Process of (2S)-1-tert-butyloxycarbonyl-4-benzyloxycarbonyl-2-hydroxymethyl-5-pyrrolidone
There total 6 articles about (2S)-1-tert-butyloxycarbonyl-4-benzyloxycarbonyl-2-hydroxymethyl-5-pyrrolidone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid;
In
methanol;
for 2h;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 98 percent / TEA, 4-DMAP / dimethylformamide / 3 h / Ambient temperature
2: 90 percent / RuO2 hydrate, 10percent aqueous NaIO4 / ethyl acetate / 1 h / Ambient temperature
3: 1.) n-butyllithium, diisopropylamine / 1.) THF, -78 deg C, 30 min; 2.) THF, -78 deg C, 1h; 3.) room temperature, 1h
4: 78 percent / p-toluenesulphonic acid / methanol / 2 h / Ambient temperature
With
dmap; ruthenium(IV) oxide; sodium periodate; n-butyllithium; TEA; toluene-4-sulfonic acid; diisopropylamine;
In
methanol; ethyl acetate; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 92 percent / LiBH4 / tetrahydrofuran / 15 h / 5 °C
2: 98 percent / TEA, 4-DMAP / dimethylformamide / 3 h / Ambient temperature
3: 90 percent / RuO2 hydrate, 10percent aqueous NaIO4 / ethyl acetate / 1 h / Ambient temperature
4: 1.) n-butyllithium, diisopropylamine / 1.) THF, -78 deg C, 30 min; 2.) THF, -78 deg C, 1h; 3.) room temperature, 1h
5: 78 percent / p-toluenesulphonic acid / methanol / 2 h / Ambient temperature
With
dmap; ruthenium(IV) oxide; sodium periodate; lithium borohydride; n-butyllithium; TEA; toluene-4-sulfonic acid; diisopropylamine;
In
tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide;
