17-acetyl-10,13-dimethyl-1,6,7,8,9,10,12,13,14,15,16,17-dodecahydro-2H-cyclopenta[a]phenanthrene-3,11-dione-3,21-diethylene ketal

Base Information

• Chemical Name: 17-acetyl-10,13-dimethyl-1,6,7,8,9,10,12,13,14,15,16,17-dodecahydro-2H-cyclopenta[a]phenanthrene-3,11-dione-3,21-diethylene ketal
• CAS No.: 2302-12-7
• Molecular Formula: C₂₅H₃₆O₅
• Molecular Weight: 416.558
• Mol file: 2302-12-7.mol

Synonyms:17-acetyl-10,13-dimethyl-1,6,7,8,9,10,12,13,14,15,16,17-dodecahydro-2H-cyclopenta[a]phenanthrene-3,11-dione-3,21-diethylene ketal

Chemical Property of 17-acetyl-10,13-dimethyl-1,6,7,8,9,10,12,13,14,15,16,17-dodecahydro-2H-cyclopenta[a]phenanthrene-3,11-dione-3,21-diethylene ketal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 17-acetyl-10,13-dimethyl-1,6,7,8,9,10,12,13,14,15,16,17-dodecahydro-2H-cyclopenta[a]phenanthrene-3,11-dione-3,21-diethylene ketal

There total 1 articles about 17-acetyl-10,13-dimethyl-1,6,7,8,9,10,12,13,14,15,16,17-dodecahydro-2H-cyclopenta[a]phenanthrene-3,11-dione-3,21-diethylene ketal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 17-acetyl-10,13-dimethyl-1,6,7,8,9,10,12,13,14,15,16,17-dodecahydro-2H-cyclopenta[a]phenanthrene-3,11-dione-3,21-diethylene ketal (2302-12-7) + 3,3-Ethylendioxy-11,21-dioxo-pregnen-(5) (5716-98-3)

Guidance literature:

With chloroform; toluene-4-sulfonic acid; ethylene glycol; Erhitzen des Reaktionsprodukts mit Pyridin;

Reference yield:

17-acetyl-10,13-dimethyl-1,6,7,8,9,10,12,13,14,15,16,17-dodecahydro-2H-cyclopenta[a]phenanthrene-3,11-dione-3,21-diethylene ketal (2302-12-7) → Progesterone (57-83-0)

Guidance literature:

Multi-step reaction with 3 steps

2: 86 percent / Li/liquid ammonia, isopropanol / tetrahydrofuran / 1.) -50 deg C, 1h 2.) -35 deg C, 2h

3: 99 percent / 60percent aq.HClO₄ / dioxane / Ambient temperature

With perchloric acid; ammonia; lithium; isopropyl alcohol; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1055/s-1986-31718

Reference yield:

17-acetyl-10,13-dimethyl-1,6,7,8,9,10,12,13,14,15,16,17-dodecahydro-2H-cyclopenta[a]phenanthrene-3,11-dione-3,21-diethylene ketal (2302-12-7) → (8S,9S,10R,11S,13S,14S,17S)-17-Acetyl-11-hydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one (600-57-7,22847-91-2)

Guidance literature:

With lithium aluminium tetrahydride; und anschliessend mit wss.HCl;

DOI:10.1021/ja01111a014

Downstream raw materials:

(8S,9S,10R,11S,13S,14S,17S)-17-Acetyl-11-hydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one

11-alpha-hydroxyprogesterone

Progesterone

11β-hydroxy-6β,11α-dimethyl-pregn-4-ene-3,20-dione