C₆₁H₇₄N₄O₁₂S

Base Information

• Chemical Name: C₆₁H₇₄N₄O₁₂S
• CAS No.: 360787-92-4
• Molecular Formula: C₆₁H₇₄N₄O₁₂S
• Molecular Weight: 1087.34
• Mol file: 360787-92-4.mol

Synonyms:C₆₁H₇₄N₄O₁₂S

Chemical Property of C₆₁H₇₄N₄O₁₂S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₆₁H₇₄N₄O₁₂S

There total 18 articles about C₆₁H₇₄N₄O₁₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

p-toluenesulfonylanhydride (4124-41-8) + C54H68N4O10 (360787-91-3) → C61H74N4O12S (360787-92-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 24h;

DOI:10.1021/jo000249z

Reference yield:

[3-(1H-Indol-3-yl)-propyl]-[1-phenyl-meth-(E)-ylidene]-amine → C61H74N4O12S (360787-92-4)

Guidance literature:

Multi-step reaction with 13 steps

1.1: sodium borohydride / methanol / 0.42 h / 0 °C

2.1: 95 percent / NaOH / tetrahydrofuran / 3 h / 20 °C

3.1: triethylamine; tert-butyl hypochlorite / tetrahydrofuran / 0.33 h

3.2: ZnCl₂ / tetrahydrofuran / 0.08 h

3.3: 89 percent / tetrahydrofuran / -60 - 20 °C

4.1: 96 percent / HCl / methanol / 2 h / 40 °C

5.1: 71 percent / toluene / 5 h / Heating

6.1: 76 percent / Lawesson's reagent / toluene / 12 h / Heating

7.1: NaBH₄ / NiCl₂

8.1: 96 percent / toluene / 12 h / Heating

9.1: triethylamine; tert-butyl hypochlorite / CH₂Cl₂ / 0.08 h / 0 °C

10.1: tetrafluoroboric acid-diethyl ether complex; silver tetrafluoroborate / acetone / 0.08 h

11.1: potassium borohydride / acetic acid / 0.17 h

12.1: aq. HCl / tetrahydrofuran / 1 h / Heating

13.1: 66 percent / diisopropylethylamine / CH₂Cl₂ / 24 h / 0 °C

With Lawessons reagent; hydrogenchloride; tetrafluoroboric acid diethyl ether; sodium hydroxide; sodium tetrahydroborate; silver tetrafluoroborate; potassium borohydride; tert-butylhypochlorite; triethylamine; N-ethyl-N,N-diisopropylamine; nickel dichloride; In tetrahydrofuran; methanol; dichloromethane; acetic acid; acetone; toluene;

DOI:10.1021/jo000249z

Reference yield:

N-benzyl-3-(1H-indol-3-yl)propan-1-amine (87400-38-2) → C61H74N4O12S (360787-92-4)

Guidance literature:

Multi-step reaction with 12 steps

1.1: 95 percent / NaOH / tetrahydrofuran / 3 h / 20 °C

2.1: triethylamine; tert-butyl hypochlorite / tetrahydrofuran / 0.33 h

2.2: ZnCl₂ / tetrahydrofuran / 0.08 h

2.3: 89 percent / tetrahydrofuran / -60 - 20 °C

3.1: 96 percent / HCl / methanol / 2 h / 40 °C

4.1: 71 percent / toluene / 5 h / Heating

5.1: 76 percent / Lawesson's reagent / toluene / 12 h / Heating

6.1: NaBH₄ / NiCl₂

7.1: 96 percent / toluene / 12 h / Heating

8.1: triethylamine; tert-butyl hypochlorite / CH₂Cl₂ / 0.08 h / 0 °C

9.1: tetrafluoroboric acid-diethyl ether complex; silver tetrafluoroborate / acetone / 0.08 h

10.1: potassium borohydride / acetic acid / 0.17 h

11.1: aq. HCl / tetrahydrofuran / 1 h / Heating

12.1: 66 percent / diisopropylethylamine / CH₂Cl₂ / 24 h / 0 °C

With Lawessons reagent; hydrogenchloride; tetrafluoroboric acid diethyl ether; sodium hydroxide; sodium tetrahydroborate; silver tetrafluoroborate; potassium borohydride; tert-butylhypochlorite; triethylamine; N-ethyl-N,N-diisopropylamine; nickel dichloride; In tetrahydrofuran; methanol; dichloromethane; acetic acid; acetone; toluene;

DOI:10.1021/jo000249z

upstream raw materials:

p-toluenesulfonylanhydride

C₅₄H₆₈N₄O₁₀

N-benzyl-3-(1H-indol-3-yl)propan-1-amine

benzyl-[3-(1H-indol-3-yl)-propyl]-carbamic acid tert-butyl ester

Refernces