4-(hydroxymethyl)-N,N-dipropylbenzenesulfonamide

Base Information

• Chemical Name: 4-(hydroxymethyl)-N,N-dipropylbenzenesulfonamide
• CAS No.: 15148-72-8
• Molecular Formula: C₁₃H₂₁NO₃S
• Molecular Weight: 271.381
• Mol file: 15148-72-8.mol

Synonyms:4-(hydroxymethyl)-N,N-dipropylbenzenesulfonamide

Chemical Property of 4-(hydroxymethyl)-N,N-dipropylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(hydroxymethyl)-N,N-dipropylbenzenesulfonamide

There total 3 articles about 4-(hydroxymethyl)-N,N-dipropylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-[(dipropylamino)sulfonyl]benzoic acid (57-66-9) → 4-(hydroxymethyl)-N,N-dipropylbenzenesulfonamide (15148-72-8)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; at 0 - 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/acs.orglett.0c02229

Reference yield:

methyl 4-(N,N-dipropylsulfamoyl)benzoate (53212-75-2) → 4-(hydroxymethyl)-N,N-dipropylbenzenesulfonamide (15148-72-8)

Guidance literature:

With C₂₂H₁₄MnN₂O₄⁽¹⁺⁾*BF₄^(1-); potassium hydride; In tetrahydrofuran; at 50 ℃; Inert atmosphere; Glovebox; Sealed tube;

DOI:10.1039/d1cc05614j

Reference yield:

→ 4-(hydroxymethyl)-N,N-dipropylbenzenesulfonamide (15148-72-8)

Guidance literature:

aus entspr. Acetat;

upstream raw materials:

4-[(dipropylamino)sulfonyl]benzoic acid

methyl 4-(N,N-dipropylsulfamoyl)benzoate

Downstream raw materials:

4-[(dipropylamino)sulfonyl]benzoic acid

Refernces

• 1、 Chakraborty, Soumi,Das, Arpan,Mandal, Swadhin K.. "Redox-active ligand based Mn(i)-catalyst for hydrosilylative ester reduction". supporting information. p. 12671 - 12674. Retrieved 2021/12/04.