4-((benzyloxy)methyl)dibenzo[b,d]furan

Base Information

• Chemical Name: 4-((benzyloxy)methyl)dibenzo[b,d]furan
• CAS No.: 1314564-72-1
• Molecular Formula: C₂₀H₁₆O₂
• Molecular Weight: 288.346
• Mol file: 1314564-72-1.mol

Synonyms:4-((benzyloxy)methyl)dibenzo[b,d]furan

Chemical Property of 4-((benzyloxy)methyl)dibenzo[b,d]furan

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 4-((benzyloxy)methyl)dibenzo[b,d]furan

There total 2 articles about 4-((benzyloxy)methyl)dibenzo[b,d]furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

potassium α-benzyloxymethyltrifluoroborate + dibenzo[b,d]furan-4-yl methanesulfonate (1314564-31-2) → 4-((benzyloxy)methyl)dibenzo[b,d]furan (1314564-72-1)

Guidance literature:

With potassium phosphate; 1,1'-bis(diisopropylphosphino)ferrocene; (2'-amino-[1,1'-biphenyl]-2-yl)palladium(II)chloride dimer; In water; tert-butyl alcohol; at 110 ℃; for 16h; Inert atmosphere;

DOI:10.1021/ol201469r

Reference yield:

4-hydroxydibenzofuran (19261-06-4) → 4-((benzyloxy)methyl)dibenzo[b,d]furan (1314564-72-1)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

2: potassium phosphate; 1,1'-bis(diisopropylphosphino)ferrocene; (2'-amino-[1,1'-biphenyl]-2-yl)palladium(II)chloride dimer / water; tert-butyl alcohol / 16 h / 110 °C / Inert atmosphere

With pyridine; potassium phosphate; 1,1'-bis(diisopropylphosphino)ferrocene; (2'-amino-[1,1'-biphenyl]-2-yl)palladium(II)chloride dimer; In dichloromethane; water; tert-butyl alcohol; 2: Suzuki-Miyaura cross coupling;

DOI:10.1021/ol201469r

upstream raw materials:

dibenzo[b,d]furan-4-yl methanesulfonate

4-hydroxydibenzofuran

Refernces