benzyl 2-(benzyloxy)-4-((4-cyclohexylbenzyl)amino)benzoate

Base Information

• Chemical Name: benzyl 2-(benzyloxy)-4-((4-cyclohexylbenzyl)amino)benzoate
• CAS No.: 1241833-16-8
• Molecular Formula: C₃₄H₃₅NO₃
• Molecular Weight: 505.657
• Mol file: 1241833-16-8.mol

Synonyms:benzyl 2-(benzyloxy)-4-((4-cyclohexylbenzyl)amino)benzoate

Chemical Property of benzyl 2-(benzyloxy)-4-((4-cyclohexylbenzyl)amino)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of benzyl 2-(benzyloxy)-4-((4-cyclohexylbenzyl)amino)benzoate

There total 8 articles about benzyl 2-(benzyloxy)-4-((4-cyclohexylbenzyl)amino)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-cyclohexylbenzaldehyde (27634-89-5) + benzyl 4-amino-2-(benzyloxy)benzoate (1241832-99-4) → benzyl 2-(benzyloxy)-4-((4-cyclohexylbenzyl)amino)benzoate (1241833-16-8)

Guidance literature:

4-cyclohexylbenzaldehyde; benzyl 4-amino-2-(benzyloxy)benzoate; With acetic acid; In methanol; at 45 ℃; for 3h; Molecular sieve; Inert atmosphere;

With sodium cyanoborohydride; In methanol; at 45 ℃; Inert atmosphere;

DOI:10.1021/jm3017255

Reference yield: 83.0%

→ benzyl 2-(benzyloxy)-4-((4-cyclohexylbenzyl)amino)benzoate (1241833-16-8)

Guidance literature:

With acetic acid; In methanol; at 45 ℃; for 3h; Inert atmosphere; Molecular sieve;

With methanol; sodium cyanoborohydride; at 20 ℃; Inert atmosphere;

Reference yield:

C34H33NO3 → benzyl 2-(benzyloxy)-4-((4-cyclohexylbenzyl)amino)benzoate (1241833-16-8)

Guidance literature:

With sodium cyanoborohydride; In methanol; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmcl.2011.06.056

upstream raw materials:

benzyl 4-amino-2-(benzyloxy)benzoate

4-cyclohexylbenzaldehyde

benzyl bromide

4-Aminosalicylic acid

Downstream raw materials:

benzyl 2-(benzyloxy)-4-(N-(4-cyclohexylbenzyl)-2-(N-methylbiphenyl-4-ylsulfonamido)acetamido)benzoate

benzyl 2-(benzyloxy)-4-(2-(4-chloro-N-methylphenylsulfonamido)-N-(4-cyclohexylbenzyl)acetamido)benzoate

benzyl 2-(benzyloxy)-4-(N-(4-cyclohexylbenzyl)-2-(N-methylnaphthalene-1-sulfonamido)acetamido)benzoate

benzyl 2-(benzyloxy)-4-(N-(4-cyclohexylbenzyl)-2-(N-methylquinoline-8-sulfonamido)acetamido)benzoate

Refernces

• 1、 -. "Substituted 2-hydroxy-4-(2-(phenylsulfonamido)acetamido)benzoic acid analogs as inhibitors of STAT protein". Page/Page column 226-227; 229-230. . Retrieved 2019/02/14.
• 2、 Haftchenary, Sina,Luchman, H. Artee,Jouk, Andriana O.,Veloso, Anthony J.,Page, Brent D. G.,Cheng, Xin Ran,Dawson, Sean S.,Grinshtein, Natalie,Shahani, Vijay M.,Kerman, Kagan,Kaplan, David R.,Griffin, Carly,Aman, Ahmed M.,Al-Awar, Rima,Weiss, Samuel,Gunning, Patrick T.. "Potent targeting of the STAT3 protein in brain cancer stem cells: A promising route for treating glioblastoma". . p. 1102 - 1107. Retrieved 2013/12/04.