α-(2-thiophenylethylamino)-o-chlorophenylacetic acid

Base Information

• Chemical Name: α-(2-thiophenylethylamino)-o-chlorophenylacetic acid
• CAS No.: 808732-87-8
• Molecular Formula: C₁₄H₁₄ClNO₂S
• Molecular Weight: 295.79
• Mol file: 808732-87-8.mol

Synonyms:α-(2-thiophenylethylamino)-o-chlorophenylacetic acid

Chemical Property of α-(2-thiophenylethylamino)-o-chlorophenylacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-(2-thiophenylethylamino)-o-chlorophenylacetic acid

There total 4 articles about α-(2-thiophenylethylamino)-o-chlorophenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-amino-(2-chlorophenyl)ethanoic acid (86169-24-6,141196-64-7,141315-50-6,88744-36-9) + 2-(thiophene-2-yl)ethyl benzenesulfonate (85567-51-7) → α-(2-thiophenylethylamino)-o-chlorophenylacetic acid (808732-87-8)

Guidance literature:

2-amino-(2-chlorophenyl)ethanoic acid; 2-(thiophene-2-yl)ethyl benzenesulfonate; With sodium hydrogencarbonate; In propiononitrile; for 6h; Heating / reflux;

In ethyl acetate; pH=~ 6; Product distribution / selectivity; Acidic conditions;

Reference yield:

[2-(2-thyenyl)ethyl]amine (30433-91-1) + o-chlorobenzoylformic acid (26118-14-9) → α-(2-thiophenylethylamino)-o-chlorophenylacetic acid (808732-87-8)

Guidance literature:

With hydrogen; 5%-palladium/activated carbon; In ethanol; for 20h; under 2250.23 Torr; Product distribution / selectivity;

Reference yield:

[2-(2-thyenyl)ethyl]amine (30433-91-1) + α-bromo-2-chlorophenyl acetic acid (29270-30-2,141109-25-3) → α-(2-thiophenylethylamino)-o-chlorophenylacetic acid (808732-87-8)

Guidance literature:

[2-(2-thyenyl)ethyl]amine; α-bromo-2-chlorophenyl acetic acid; With potassium hydroxide; In methanol; water; at 40 ℃; for 4h;

With hydrogenchloride; In methanol; water; at 20 ℃; for 2h; pH=4; Product distribution / selectivity;

upstream raw materials:

2-amino-(2-chlorophenyl)ethanoic acid

2-(thiophene-2-yl)ethyl benzenesulfonate

[2-(2-thyenyl)ethyl]amine

o-chlorobenzoylformic acid

Downstream raw materials:

(+/-)-N-(2-(2-thienyl)ethyl)-2-chlorophenyl glycine hydrochloride

2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridine-5(4H)-yl)acetic acid

Refernces

• 1、 -. "PROCESS FOR THE SYNTHESIS OF CLOPIDOGREL AND NEW FORMS OF PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF". Page/Page column 3; 34. . Retrieved 2008/06/13.