8-methyl-7-phenyltheophylline

Base Information

• Chemical Name: 8-methyl-7-phenyltheophylline
• CAS No.: 36748-66-0
• Molecular Formula: C₁₄H₁₄N₄O₂
• Molecular Weight: 270.291
• Mol file: 36748-66-0.mol

Synonyms:8-methyl-7-phenyltheophylline

Chemical Property of 8-methyl-7-phenyltheophylline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-methyl-7-phenyltheophylline

There total 4 articles about 8-methyl-7-phenyltheophylline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

bromobenzene (108-86-1,52753-63-6) + 8-methyltheophylline (830-65-9) → 8-methyl-7-phenyltheophylline (36748-66-0)

Guidance literature:

With N⁴,N⁷-bis(2-hydroxyethyl)-1,10-phenanthroline-4,7-diamine; sodium L-ascorbate; potassium hydroxide; copper(I) bromide; In water; N,N-dimethyl-formamide; at 120 ℃; for 48h; regioselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1039/c3cc48642g

Reference yield: 12.0%

iodobenzene (591-50-4) + 8-methyltheophylline (830-65-9) → 8-methyl-7-phenyltheophylline (36748-66-0)

Guidance literature:

With N⁴,N⁷-bis(2-hydroxyethyl)-1,10-phenanthroline-4,7-diamine; sodium L-ascorbate; potassium hydroxide; copper(I) bromide; In water; N,N-dimethyl-formamide; at 120 ℃; for 48h; regioselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1039/c3cc48642g

Reference yield:

4,5-Diamino-1,3-dimethyluracil (5440-00-6) → 8-methyl-7-phenyltheophylline (36748-66-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: pyridine / 0.33 h / 110 °C / Microwave irradiation

1.2: 16 h / 60 °C

2.1: N⁴,N⁷-bis(2-hydroxyethyl)-1,10-phenanthroline-4,7-diamine; copper(I) bromide; potassium hydroxide; sodium L-ascorbate / water; N,N-dimethyl-formamide / 48 h / 120 °C / Inert atmosphere; Sealed tube

With pyridine; N⁴,N⁷-bis(2-hydroxyethyl)-1,10-phenanthroline-4,7-diamine; sodium L-ascorbate; potassium hydroxide; copper(I) bromide; In water; N,N-dimethyl-formamide;

DOI:10.1039/c3cc48642g

upstream raw materials:

bromobenzene

8-methyltheophylline

iodobenzene

4,5-Diamino-1,3-dimethyluracil

Refernces