(+/-)-3-methylene-1,5-diphenylpentanediol

Base Information

• Chemical Name: (+/-)-3-methylene-1,5-diphenylpentanediol
• CAS No.: 71370-00-8
• Molecular Formula: C₁₈H₂₀O₂
• Molecular Weight: 268.356
• Mol file: 71370-00-8.mol

Synonyms:(+/-)-3-methylene-1,5-diphenylpentanediol

Chemical Property of (+/-)-3-methylene-1,5-diphenylpentanediol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-3-methylene-1,5-diphenylpentanediol

There total 12 articles about (+/-)-3-methylene-1,5-diphenylpentanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-(Hydroxymethyl)allyl alcohol (3513-81-3) + benzaldehyde (100-52-7) → (+/-)-3-methylene-1,5-diphenylpentanediol (71370-00-8)

Guidance literature:

With tin(ll) chloride; In various solvent(s); at 50 ℃; for 15h;

DOI:10.1039/cc9960001585

Reference yield: 92.0%

2-chloromethyl-3-chloroprop-1-ene (1871-57-4) + 2-(Hydroxymethyl)allyl alcohol (3513-81-3) → (+/-)-3-methylene-1,5-diphenylpentanediol (71370-00-8)

Guidance literature:

With tin(ll) chloride; bis(benzonitrile)palladium(II) dichloride; In N,N-dimethyl-formamide; for 72h; Ambient temperature;

DOI:10.1039/cc9960001585

Reference yield: 90.0%

2-methylidenetrimethylene carbonate (3775-32-4) + benzaldehyde (100-52-7) → (+/-)-3-methylene-1,5-diphenylpentanediol (71370-00-8)

Guidance literature:

With bis(benzonitrile)palladium(II) dichloride; tin(ll) chloride; In various solvent(s); for 4h; Ambient temperature;

DOI:10.1080/00397919508013837

upstream raw materials:

benzaldehyde

isobutene

2-chloromethyl-3-chloroprop-1-ene

1,1-bis(dipropylborylmethyl)ethylene

Refernces

• 1、 Yu, Chan-Mo,Lee, Jae-Young,So, Byungran,Hong, Junghyun. "Sequential catalytic asymmetric allylic transfer reaction: Enantioselective and diastereoselective construction of tetrahydropyran units". . p. 161 - 163. Retrieved 2007/10/03.
• 2、 Masuyama, Yoshiro,Kagawa, Masaaki,Kurusu, Yasuhiko. "Palladium-catalysed carbonyl allylation by 2-methylenepropane-1,3-diol". . p. 1585 - 1586. Retrieved 2007/10/03.