Multi-step reaction with 6 steps
1.1: triethylamine / methanol / 6 h / 20 °C
2.1: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane / 0.67 h / 20 °C / Inert atmosphere
2.2: 18 h / 20 °C / Inert atmosphere
3.1: ammonium formate; palladium on activated charcoal / methanol / 3.5 h / 65 °C
4.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 12 h / 20 °C
5.1: [18F]fluoride ion, cyclotron produced, NCA; tetraethylammonium bicarbonate; tetrakis(pyridine)copper(II) bis(trifluoromethanesulfonate) / butan-1-ol; N,N-dimethyl acetamide / 0.17 h / 110 °C / Sealed tube
6.1: trifluoroacetic acid / dichloromethane / 0.08 h / 80 °C
With
palladium on activated charcoal; tetrakis(pyridine)copper(II) bis(trifluoromethanesulfonate); benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; ammonium formate; potassium carbonate; tetraethylammonium bicarbonate; triethylamine; trifluoroacetic acid; potassium iodide; [18F]fluoride ion, cyclotron produced, NCA;
In
methanol; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1021/acsmedchemlett.0c00658