Technology Process of 4-(2,4-dimethylphenyl)-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
There total 5 articles about 4-(2,4-dimethylphenyl)-7-(2-trimethylsilanylethoxymethyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
triethylamine; trifluoroacetic anhydride;
In
dichloromethane;
at 0 - 20 ℃;
DOI:10.1016/j.bmc.2012.08.050
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: trichlorophosphate / 2.5 h / 100 °C / Inert atmosphere
2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 1.5 h / 0 - 20 °C
3.1: bis-triphenylphosphine-palladium(II) chloride; sodium hydrogencarbonate / N,N-dimethyl-formamide; water / 1.5 h / 80 °C / Inert atmosphere
4.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 18 h / 20 °C / Cooling with ice
5.1: n-butyllithium / hexane; tetrahydrofuran / 0.03 h / -78 °C
5.2: -78 - 20 °C
6.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 0.17 h
6.2: 0.25 h / 20 °C
7.1: triethylamine; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C
With
bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; n-butyllithium; oxalyl dichloride; sodium hydride; sodium hydrogencarbonate; triethylamine; N,N-dimethyl-formamide; trifluoroacetic anhydride; trichlorophosphate;
In
tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmc.2012.08.050