4-(N-pyrrolidino)acetophenone tosylhydrazone

Base Information

• Chemical Name: 4-(N-pyrrolidino)acetophenone tosylhydrazone
• CAS No.: 1373368-76-3
• Molecular Formula: C₁₉H₂₃N₃O₂S
• Molecular Weight: 357.477
• Mol file: 1373368-76-3.mol

Synonyms:4-(N-pyrrolidino)acetophenone tosylhydrazone

Chemical Property of 4-(N-pyrrolidino)acetophenone tosylhydrazone

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-(N-pyrrolidino)acetophenone tosylhydrazone

There total 1 articles about 4-(N-pyrrolidino)acetophenone tosylhydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N-(4-acetylphenyl)pyrrolidine (21557-09-5) + toluene-4-sulfonic acid hydrazide (1576-35-8) → 4-(N-pyrrolidino)acetophenone tosylhydrazone (1373368-76-3)

Guidance literature:

With hydrogenchloride; In ethanol; water; at 20 ℃; for 3h;

DOI:10.1021/ol300652k

Reference yield: 52.0%

N-methoxy-N-methylbenzamide (6919-61-5) + 4-(N-pyrrolidino)acetophenone tosylhydrazone (1373368-76-3) → 2-(4-pyrrolidinophenyl)-1-phenylprop-2-enone (1373368-73-0)

Guidance literature:

4-(N-pyrrolidino)acetophenone tosylhydrazone; With dimesitylmagnesium; lithium chloride; In tetrahydrofuran; at 40 ℃; for 3h;

N-methoxy-N-methylbenzamide; In tetrahydrofuran; at 40 ℃; for 1h;

With water-d2; In tetrahydrofuran;

DOI:10.1021/ol300652k

Reference yield:

4-(N-pyrrolidino)acetophenone tosylhydrazone (1373368-76-3) → 1-(4-vinylphenyl)pyrrolidine (1373368-72-9) + α-deuterio-1-(4-vinylphenyl)pyrrolidine (1373368-71-8)

Guidance literature:

4-(N-pyrrolidino)acetophenone tosylhydrazone; With dimesitylmagnesium; lithium chloride; In tetrahydrofuran; at 40 ℃; for 3h;

With water-d2; In tetrahydrofuran;

DOI:10.1021/ol300652k

upstream raw materials:

N-(4-acetylphenyl)pyrrolidine

toluene-4-sulfonic acid hydrazide

Downstream raw materials:

1-(4-vinylphenyl)pyrrolidine

α-deuterio-1-(4-vinylphenyl)pyrrolidine

2-(4-pyrrolidinophenyl)-1-phenylprop-2-enone

Refernces