2-ACETAMIDO-5-PYRIDINECARBOXYLIC ACID

Base Information

• Chemical Name: 2-ACETAMIDO-5-PYRIDINECARBOXYLIC ACID
• CAS No.: 21550-48-1
• Molecular Formula: C8H8N2O3
• Molecular Weight: 180.163
• Hs Code.: 29333990
• Mol file: 21550-48-1.mol

Synonyms:Nicotinicacid, 6-acetamido- (6CI,7CI,8CI);6-(Acetylamino)nicotinic acid;6-(Acetylamino)pyridine-3-carboxylic acid;6-Acetamidonicotinic acid;6-Acetamidopyridine-3-carboxylic acid;NSC 117746;

Chemical Property of 2-ACETAMIDO-5-PYRIDINECARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 3.52E-10mmHg at 25°C
• Melting Point: 276-278°C
• Refractive Index: 1.628
• Boiling Point: 484 °C at 760 mmHg
• PKA: 14.18±0.70(Predicted)
• Flash Point: 246.5 °C
• PSA: 79.29000
• Density: 1.404g/cm³
• LogP: 0.81120
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

6-AcetamidonicotinicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-ACETAMIDO-5-PYRIDINECARBOXYLIC ACID

There total 4 articles about 2-ACETAMIDO-5-PYRIDINECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

6-aminonicotinic acid (3167-49-5) + acetic anhydride (108-24-7) → 6-(acetylamino)pyridine-3-carboxylic acid (21550-48-1)

Guidance literature:

In pyridine; at 130 ℃; for 24h;

DOI:10.1016/S0040-4020(00)00733-X

Reference yield: 45.0%

N-(5-methylpyridin-2-yl)acetamide (4931-47-9) → 6-(acetylamino)pyridine-3-carboxylic acid (21550-48-1)

Guidance literature:

With potassium permanganate; sodium hydroxide; In water; Reflux;

DOI:10.1080/10610278.2010.483732

Reference yield:

(5-methyl-pyridin-2-yl)amine (1603-41-4) → 6-(acetylamino)pyridine-3-carboxylic acid (21550-48-1)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid

2: aqueous KMnO₄

With potassium permanganate; acetic acid;

upstream raw materials:

N-(5-methylpyridin-2-yl)acetamide

6-aminonicotinic acid

acetic anhydride

(5-methyl-pyridin-2-yl)amine

Downstream raw materials:

6-acetamido-N-[2-methyl-5-(4-phenylpiperidine-1-carbonyl)phenyl]pyridine-3-carboxamide

2-(6-amino nicotinamidomethyl)-1-(3,3-diphenylpropyl) pyrrolidine

6-amino-N-[1-(1-methyl-2-phenyl-ethyl)-pyrrolidin-2-ylmethyl]-nicotinamide

6-amino-N-[1-(3-phenyl-propyl)-pyrrolidin-2-ylmethyl]-nicotinamide

Refernces

• 1、 Zafar, Abdullah,Geib, Steven J.,Hamuro, Yoshitomo,Carr, Andrew J.,Hamilton, Andrew D.. "Hydrogen bonding control of molecular self-assembly: Aggregation behavior of acylaminopyridine-carboxylic acid derivatives in solution and the solid state". . p. 8419 - 8427. Retrieved 2000.
• 2、 -. "INDOLYLMETHYL-MORPHOLINE DERIVATIVES AS KINASE INHIBITORS". Page/Page column 43. . Retrieved 2010/12/31.