Selinondiacetat

Base Information

• Chemical Name: Selinondiacetat
• CAS No.: 39953-45-2
• Molecular Formula: C₂₄H₂₄O₇
• Molecular Weight: 424.45
• Mol file: 39953-45-2.mol

Synonyms:Selinondiacetat

Chemical Property of Selinondiacetat

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Selinondiacetat

There total 8 articles about Selinondiacetat which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

3-methyl-2-buten-1-ol (556-82-1) + (±)-5,7-diacetoxy-4'-hydroxyflavan-4-one (517892-90-9) → Selinondiacetat (39953-45-2)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 2.5h;

DOI:10.1515/HC.2002.8.6.543

Reference yield:

p-benzyloxybenzaldehyde (4397-53-9) → Selinondiacetat (39953-45-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 54 percent / aq. potassium hydroxide / ethanol / 120 h / 40 °C

2.1: aq. HCl / methanol / 20 °C

2.2: 43.9 percent / sodium acetate / methanol / 5 h / 70 °C

3.1: 50 percent / pyridine / 48 h / 20 °C

4.1: 76 percent / hydrogen / Pd/C / methanol / 20 °C

5.1: 60 percent / triphenylphosphane; diisopropyl azodicarboxylate / tetrahydrofuran / 2.5 h / 0 - 20 °C

With pyridine; hydrogenchloride; potassium hydroxide; di-isopropyl azodicarboxylate; hydrogen; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; 5.1: Mitsunobu reaction;

DOI:10.1515/HC.2002.8.6.543

Reference yield:

2'-hydroxy-4',6'-bis(methoxymethoxy)acetophenone (65490-09-7) → Selinondiacetat (39953-45-2)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 54 percent / aq. potassium hydroxide / ethanol / 120 h / 40 °C

2.1: aq. HCl / methanol / 20 °C

2.2: 43.9 percent / sodium acetate / methanol / 5 h / 70 °C

3.1: 50 percent / pyridine / 48 h / 20 °C

4.1: 76 percent / hydrogen / Pd/C / methanol / 20 °C

5.1: 60 percent / triphenylphosphane; diisopropyl azodicarboxylate / tetrahydrofuran / 2.5 h / 0 - 20 °C

With pyridine; hydrogenchloride; potassium hydroxide; di-isopropyl azodicarboxylate; hydrogen; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; 5.1: Mitsunobu reaction;

DOI:10.1515/HC.2002.8.6.543

upstream raw materials:

3-methyl-2-buten-1-ol

(±)-5,7-diacetoxy-4'-hydroxyflavan-4-one

p-benzyloxybenzaldehyde

2'-hydroxy-4',6'-bis(methoxymethoxy)acetophenone

Downstream raw materials:

rac-5,7-dihydroxy-2-[4-(3-methylbut-2-enyloxy)phenyl]chroman-4-one

Refernces

• 1、 Kenez, Agnes,Juhasz, Laszlo,Antus, Sandor. "A simple synthesis of selinone, an antifungal component of Monotes engleri". . p. 543 - 548. Retrieved 2007/10/03.