(E)-4-fluoro-2-methyl-6-styrylaniline

Base Information

• Chemical Name: (E)-4-fluoro-2-methyl-6-styrylaniline
• CAS No.: 1054568-26-1
• Molecular Formula: C₁₅H₁₄FN
• Molecular Weight: 227.281
• Mol file: 1054568-26-1.mol

Synonyms:(E)-4-fluoro-2-methyl-6-styrylaniline

Chemical Property of (E)-4-fluoro-2-methyl-6-styrylaniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-4-fluoro-2-methyl-6-styrylaniline

There total 1 articles about (E)-4-fluoro-2-methyl-6-styrylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-bromo-4-fluoro-6-methyl-phenylamine (202865-77-8) + trans-2-phenylvinylboronic acid (6783-05-7) → (E)-4-fluoro-2-methyl-6-styrylaniline (1054568-26-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; water; toluene; for 24h; Reflux;

DOI:10.1002/anie.200800689

Reference yield: 91.0%

1-bromo-4-methoxy-benzene (104-92-7) + (E)-4-fluoro-2-methyl-6-styrylaniline (1054568-26-1) → (E)-4-fluoro-N-(4-methoxyphenyl)-2-methyl-6-styrylaniline

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; sodium tert-pentoxide; In toluene; at 80 ℃; for 1h; Inert atmosphere; Schlenk technique;

DOI:10.1002/anie.201205137

Reference yield: 74.0%

(E)-4-fluoro-2-methyl-6-styrylaniline (1054568-26-1) → C15H12FN3 (1054566-96-9)

Guidance literature:

(E)-4-fluoro-2-methyl-6-styrylaniline; With acetic acid; sodium nitrite; In water; at 0 ℃;

With sodium azide; In water; acetic acid; at 0 - 20 ℃;

DOI:10.1002/anie.200800689

upstream raw materials:

2-bromo-4-fluoro-6-methyl-phenylamine

trans-2-phenylvinylboronic acid

Downstream raw materials:

C₁₅H₁₂FN₃

Refernces