2-bromo-4-nitro-N,N-dimethylbenzylamine

Base Information

• Chemical Name: 2-bromo-4-nitro-N,N-dimethylbenzylamine
• CAS No.: 267243-37-8
• Molecular Formula: C₉H₁₁BrN₂O₂
• Molecular Weight: 259.103
• Mol file: 267243-37-8.mol

Synonyms:2-bromo-4-nitro-N,N-dimethylbenzylamine

Chemical Property of 2-bromo-4-nitro-N,N-dimethylbenzylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-bromo-4-nitro-N,N-dimethylbenzylamine

There total 1 articles about 2-bromo-4-nitro-N,N-dimethylbenzylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

2-bromo-1-(bromomethyl)-4-nitrobenzene (940-05-6) + dimethyl amine (124-40-3) → 2-bromo-4-nitro-N,N-dimethylbenzylamine (267243-37-8)

Guidance literature:

In methanol; water; at 20 ℃; for 1h;

DOI:10.1021/jm990482t

Reference yield: 96.0%

2-bromo-4-nitro-N,N-dimethylbenzylamine (267243-37-8) → 4-amino-2-bromo-N,N-dimethylbenzylamine (267243-38-9)

Guidance literature:

With iron; acetic acid; In ethanol; for 0.333333h; Heating;

DOI:10.1021/jm990482t

Reference yield:

2-bromo-4-nitro-N,N-dimethylbenzylamine (267243-37-8) → 6-amino-4-[N-[3-bromo-4-(dimethylaminomethyl)phenyl]amino]quinazoline (267243-42-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / Fe; aq. HOAc / ethanol / 0.33 h / Heating

2: Et₃N / propan-2-ol / 3 h / Heating

3: 67 percent / Fe; aq. HOAc / ethanol / 0.33 h / Heating

With iron; acetic acid; triethylamine; In ethanol; isopropyl alcohol; 1: Reduction / 2: Condensation / 3: Reduction;

DOI:10.1021/jm990482t

upstream raw materials:

2-bromo-1-(bromomethyl)-4-nitrobenzene

dimethyl amine

Downstream raw materials:

4-amino-2-bromo-N,N-dimethylbenzylamine

6-amino-4-[N-[3-bromo-4-(dimethylaminomethyl)phenyl]amino]quinazoline

4-[N-[3-bromo-4-(dimethylaminomethyl)phenyl]amino]-6-nitroquinazoline

Refernces