4-Benzyloxy-2-bromonitrobenzene

Base Information

• Chemical Name: 4-Benzyloxy-2-bromonitrobenzene
• CAS No.: 165190-62-5
• Molecular Formula: C13H10 Br N O3
• Molecular Weight: 308.131
• Hs Code.: 2909309090
• Mol file: 165190-62-5.mol

Synonyms:4-Benzyloxy-2-bromo-1-nitrobenzene

Chemical Property of 4-Benzyloxy-2-bromonitrobenzene

Chemical Property:

• Refractive Index: 1.626
• PSA: 55.05000
• LogP: 4.45950

Purity/Quality:

98.5% ^*data from raw suppliers

4-Benzyloxy-2-bromonitrobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Benzyloxy-2-bromonitrobenzene

There total 2 articles about 4-Benzyloxy-2-bromonitrobenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

3-bromo-4-nitrophenol (5470-65-5) + benzyl bromide (100-39-0) → 4-(benzyloxy)-2-bromo-1-nitrobenzene (165190-62-5)

Guidance literature:

3-bromo-4-nitrophenol; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h; Inert atmosphere;

benzyl bromide; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1021/ol401197n

Reference yield:

3-Bromophenol (591-20-8) → 4-(benzyloxy)-2-bromo-1-nitrobenzene (165190-62-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sulfuric acid; sodium nitrate / water; ethanol / 20 - 30 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.33 h / 20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

With sodium nitrate; sulfuric acid; potassium carbonate; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1021/ol401197n

Reference yield: 96.0%

4-(benzyloxy)-2-bromo-1-nitrobenzene (165190-62-5) → 4-(benzyloxy)-2-bromoaniline (215712-11-1)

Guidance literature:

With hydrogenchloride; iron; In ethanol; water; for 1h; Heating;

DOI:10.1021/ol026849x

upstream raw materials:

3-bromo-4-nitrophenol

benzyl bromide

3-Bromophenol

Downstream raw materials:

methyl 2-(methylthio)benzoate

4-benzyloxy-2-(2'-carbomethoxy)thiophenylnitrobenzene

4-(benzyloxy)-2-bromoaniline

2-trimethylsilanyl-ethanesulfonic acid (2-bromo-4-hydroxy-phenyl)-amide

Refernces

• 1、 Jung, Kwan-Young,Vanommeslaeghe, Kenno,Lanning, Maryanna E.,Yap, Jeremy L.,Gordon, Caryn,Wilder, Paul T.,Mackerell, Alexander D.,Fletcher, Steven. "Amphipathic α-helix mimetics based on a 1,2-diphenylacetylene scaffold". supporting information. p. 3234 - 3237. Retrieved 2013/07/26.
• 2、 Warawa,Migler,Ohnmacht,Needles,Gatos,McLaren,Nelson,Kirkland. "Behavioral approach to nondyskinetic dopamine antagonists: Identification of Seroquel". . p. 372 - 389. Retrieved 2007/10/03.