(-)-ALPHA-(4-CHLOROPHENYL)BENZYLAMINE (+)-TARTRATE SALT

Base Information

• Chemical Name: (-)-ALPHA-(4-CHLOROPHENYL)BENZYLAMINE (+)-TARTRATE SALT
• CAS No.: 163837-57-8
• Molecular Formula: C13H12ClN
• Molecular Weight: 217.698
• Mol file: 163837-57-8.mol

Synonyms:(-)-4-Chlorobenzhydrylamine;(-)-[(4-Chlorophenyl)phenylmethyl]amine;(R)-a-(4-Chlorophenyl)benzylamine;

Chemical Property of (-)-ALPHA-(4-CHLOROPHENYL)BENZYLAMINE (+)-TARTRATE SALT

Chemical Property:

• Boiling Point: 336.8 °C at 760 mmHg
• PKA: 8.08±0.10(Predicted)
• Flash Point: 194.3 °C
• PSA: 141.08000
• Density: 1.175g/cm³
• LogP: 1.96580
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

(R)-(4-Chlorophenyl)(phenyl)methanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: alpha-(4-Chlorophenyl)benzylamine (+)-tartrate salt is a useful research chemical.

Technology Process of (-)-ALPHA-(4-CHLOROPHENYL)BENZYLAMINE (+)-TARTRATE SALT

There total 46 articles about (-)-ALPHA-(4-CHLOROPHENYL)BENZYLAMINE (+)-TARTRATE SALT which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(-)-(R)-Phenyl N-(4-chlorobenzhydryl)carbamate → (R)-(4-chlorophenyl)(phenyl)methylamine (163837-57-8)

Guidance literature:

With lithium hydroxide; water; In acetonitrile; at 50 ℃; for 3h;

DOI:10.1055/s-2000-6391

Reference yield: 99.0%

(R)-N-((4-chlorophenyl)(phenyl)methyl)-N’,N’-dimethylsulfamide (898231-59-9) → (R)-(4-chlorophenyl)(phenyl)methylamine (163837-57-8)

Guidance literature:

With Trimethylenediamine; for 0.5h; enantioselective reaction; Microwave irradiation;

DOI:10.1021/acs.orglett.7b00776

Reference yield: 95.0%

(R)-N-tert-butyloxycarbonyl-α-(4-chlorophenyl)benzylamine (1000693-79-7) → (R)-(4-chlorophenyl)(phenyl)methylamine (163837-57-8)

Guidance literature:

With hydrogenchloride; In methanol; dichloromethane; at 0 - 20 ℃; for 4h; Inert atmosphere;

DOI:10.1002/anie.201915459

upstream raw materials:

(R)-(-)-N-[(1E)-(4-chlorophenyl)methylene]-2-methyl-2-propanesulfinamide

(R)-(+)-N-[(4-chlorophenyl)(phenyl)methyl]formamide

triphenylborane

phenyltriisopropoxytitanium(IV)

Downstream raw materials:

(α¹R)-4-chloro-α-phenyl-benzenemethanamine hydrochloride

4-chlorobenzophenone

levocetirizine

(R)-N-tert-butyloxycarbonyl-α-(4-chlorophenyl)benzylamine

Refernces

• 1、 Jagt, Richard B. C.,Toullec, Patrick Y.,Geerdink, Danny,De Vries, Johannes G.,Feringa, Ben L.,Minnaard, Adriaan J.. "A ligand-library approach to the highly efficient rhodium/phosphoramidite- catalyzed asymmetric arylation of N,N-dimethylsulfamoyl-protected aldimines". . p. 2789 - 2791. Retrieved 2006.
• 2、 -. "Preparation method of levocetirizine". Paragraph 0008-0021. . Retrieved 2020/04/17.
• 3、 Dawood, Ayad W. H.,Wei?, Martin S.,Schulz, Christian,Pavlidis, Ioannis V.,Iding, Hans,de Souza, Rodrigo O. M. A.,Bornscheuer, Uwe T.. "Isopropylamine as Amine Donor in Transaminase-Catalyzed Reactions: Better Acceptance through Reaction and Enzyme Engineering". . p. 3943 - 3949. Retrieved 2018/07/31.