mecilizine

Base Information

• Chemical Name: mecilizine
• CAS No.: 163837-50-1
• Molecular Formula: C₂₅H₂₇ClN₂
• Molecular Weight: 390.956
• Mol file: 163837-50-1.mol

Synonyms:

Chemical Property of mecilizine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of mecilizine

There total 10 articles about mecilizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-(4-chlorobenzhydryl)piperazine (303-26-4) + sodium hydroxy(m-tolyl)methanesulfonate → meclizine (569-65-3,163837-49-8,163837-50-1,189298-48-4,189298-47-3)

Guidance literature:

With 2-picoline borane complex; In methanol; water; at 60 ℃; for 6h; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.orglett.1c02604

Reference yield: 87.0%

N-(4-chlorobenzhydryl)piperazine (303-26-4) + 4-nitrophenyl bis(carbomethoxy) 3-(3-methylbenzyl)ylide → meclizine (569-65-3,163837-49-8,163837-50-1,189298-48-4,189298-47-3)

Guidance literature:

With trifluorormethanesulfonic acid; In dichloromethane; at 20 ℃; for 24h; Molecular sieve;

DOI:10.1016/j.cclet.2021.06.069

Reference yield: 87.0%

N-(4-chlorobenzhydryl)piperazine (303-26-4) + m-tolyl aldehyde (620-23-5) → meclizine (569-65-3,163837-49-8,163837-50-1,189298-48-4,189298-47-3)

Guidance literature:

With formic acid; boron trifluoride diethyl etherate; In acetonitrile; at 85 ℃; for 5h; Green chemistry;

DOI:10.1039/d1gc01468d

upstream raw materials:

1-(3-methylbenzyl)piperazine

4-chlorobenzaldehyde

N-(4-chlorobenzhydryl)piperazine

m-tolyl aldehyde

Refernces

• 1、 Cai, Lei,Chen, Qi,Fang, Jing,Li, Ting,Liao, Zhiwen,Ma, Xiang,Meng, Lingkui,Sun, Jiuchang,Wan, Qian,Zeng, Jing. "Discriminating non-ylidic carbon-sulfur bond cleavages of sulfonium ylides for alkylation and arylation reactions". supporting information. . Retrieved 2021/07/25.
• 2、 Ouyang, Lu,Xia, Yanping,Liao, Jianhua,Luo, Renshi. "One-Pot Transfer Hydrogenation Reductive Amination of Aldehydes and Ketones by Iridium Complexes “on Water”". . p. 6387 - 6391. Retrieved 2020/09/11.