2-epi-largazole

Base Information

• Chemical Name: 2-epi-largazole
• CAS No.: 1196806-45-7
• Molecular Formula: C₂₉H₄₂N₄O₅S₃
• Molecular Weight: 622.874
• Mol file: 1196806-45-7.mol

Synonyms:2-epi-largazole

Chemical Property of 2-epi-largazole

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-epi-largazole

There total 2 articles about 2-epi-largazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

C58H64N4O8S3 (1263375-82-1) → largazole (1009815-87-5) + 2-epi-largazole (1196806-45-7)

Guidance literature:

C₅₈H₆₄N₄O₈S₃; With diethylamine; In dichloromethane; at 20 - 25 ℃; for 3h; Inert atmosphere;

With 1-hydroxy-7-azabenzotriazole; N-ethyl-N,N-diisopropylamine; HATU; In acetonitrile; at 20 - 25 ℃; for 12h; Inert atmosphere;

DOI:10.1055/s-0029-1216931

Reference yield:

C43H54N4O6S3 → largazole (1009815-87-5) + 2-epi-largazole (1196806-45-7)

Guidance literature:

C₄₃H₅₄N₄O₆S₃; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 - 25 ℃; for 0.166667h;

With 1-hydroxy-7-aza-benzotriazole; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 - 25 ℃; for 12h;

DOI:10.1021/jo102478x

upstream raw materials:

C₅₈H₆₄N₄O₈S₃

Refernces

• 1、 Wang, Bo,Huang, Po-Hsien,Chen, Ching-Shih,Forsyth, Craig J.. "Total syntheses of the histone deacetylase inhibitors largazole and 2-epi-largazole: Application of N-Heterocyclic carbene mediated acylations in complex molecule synthesis". . p. 1140 - 1150. Retrieved 2011/05/05.