Technology Process of (S)-3-[(S)-2-methylamino-1-(4-trifluoromethylphenoxy)ethyl]pyrrolidine-1-carboxylic acid t-butyl ester trifluoroacetate
There total 6 articles about (S)-3-[(S)-2-methylamino-1-(4-trifluoromethylphenoxy)ethyl]pyrrolidine-1-carboxylic acid t-butyl ester trifluoroacetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N-methyl-2,2,2-trifluoroacetamide;
With
potassium hydride;
In
N,N-dimethyl-formamide;
at 0 ℃;
for 0.25h;
C25H30F3NO6S;
In
N,N-dimethyl-formamide;
at 60 ℃;
trifluoroacetic acid;
In
water; acetic acid;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: dihydrogen peroxide / pyridine-3-carbonitrile; methyltrioxorhenium(VII) / water / 2 h / Cooling with ice
2.1: sodium hydride / 50 °C / Inert atmosphere
2.2: 50 °C
3.1: sodium hydride / N,N-dimethyl-formamide / 3.17 h / 20 - 90 °C / Inert atmosphere
4.1: hydrogen / palladium 10% on activated carbon / methanol / 760.05 Torr
5.1: 1,4-diaza-bicyclo[2.2.2]octane / dichloromethane / 1 h / 0 - 20 °C
6.1: potassium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C
6.2: 60 °C
With
1,4-diaza-bicyclo[2.2.2]octane; hydrogen; dihydrogen peroxide; potassium hydride; sodium hydride;
pyridine-3-carbonitrile; palladium 10% on activated carbon; methyltrioxorhenium(VII);
In
methanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydride / 50 °C / Inert atmosphere
1.2: 50 °C
2.1: sodium hydride / N,N-dimethyl-formamide / 3.17 h / 20 - 90 °C / Inert atmosphere
3.1: hydrogen / palladium 10% on activated carbon / methanol / 760.05 Torr
4.1: 1,4-diaza-bicyclo[2.2.2]octane / dichloromethane / 1 h / 0 - 20 °C
5.1: potassium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C
5.2: 60 °C
With
1,4-diaza-bicyclo[2.2.2]octane; hydrogen; potassium hydride; sodium hydride;
palladium 10% on activated carbon;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
