N-(2-(1-cyano-2-oxocycloheptyl)ethyl)mesityl sulfonamide

Base Information

• Chemical Name: N-(2-(1-cyano-2-oxocycloheptyl)ethyl)mesityl sulfonamide
• CAS No.: 1039756-13-2
• Molecular Formula: C₁₉H₂₆N₂O₃S
• Molecular Weight: 362.493
• Mol file: 1039756-13-2.mol

Synonyms:N-(2-(1-cyano-2-oxocycloheptyl)ethyl)mesityl sulfonamide

Chemical Property of N-(2-(1-cyano-2-oxocycloheptyl)ethyl)mesityl sulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-(1-cyano-2-oxocycloheptyl)ethyl)mesityl sulfonamide

There total 4 articles about N-(2-(1-cyano-2-oxocycloheptyl)ethyl)mesityl sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

N-mesitylenesulfonyl aziridine (960054-45-9) + 2-oxocycloheptanecarbonitrile (7391-45-9) → N-(2-(1-cyano-2-oxocycloheptyl)ethyl)mesityl sulfonamide (1039756-13-2) + C19H26N2O3S (1453207-01-6)

Guidance literature:

2-oxocycloheptanecarbonitrile; With 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; In tetrahydrofuran; at 25 ℃; for 0.166667h; Inert atmosphere;

N-mesitylenesulfonyl aziridine; In tetrahydrofuran; at 65 ℃; for 6h; Catalytic behavior; Inert atmosphere;

DOI:10.1002/chem.201203825

Reference yield: 43.0%

N-mesitylenesulfonyl aziridine (960054-45-9) + 2-oxocycloheptanecarbonitrile (7391-45-9) → C19H28N2O3S (1039756-14-3) + N-(2-(1-cyano-2-oxocycloheptyl)ethyl)mesityl sulfonamide (1039756-13-2)

Guidance literature:

With 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; In tetrahydrofuran; at 65 ℃; for 6.16667h;

DOI:10.1039/b802447b

Reference yield:

2-mesitylenesulphonyl chloride (773-64-8) → N-(2-(1-cyano-2-oxocycloheptyl)ethyl)mesityl sulfonamide (1039756-13-2) + C19H26N2O3S (1453207-01-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: pyridine / -10 - 20 °C / Inert atmosphere

2.1: potassium hydroxide / water; toluene / 25 °C / Inert atmosphere

3.1: 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine / tetrahydrofuran / 0.17 h / 25 °C / Inert atmosphere

3.2: 6 h / 65 °C / Inert atmosphere

With pyridine; 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; potassium hydroxide; In tetrahydrofuran; water; toluene;

DOI:10.1002/chem.201203825

upstream raw materials:

N-mesitylenesulfonyl aziridine

2-oxocycloheptanecarbonitrile

2-mesitylenesulphonyl chloride

2,4-(dimesitylsulfonyl)ethanolamine

Refernces

• 1、 Moss, Thomas A.,Alba, Aurelie,Hepworth, David,Dixon, Darren J.. "Efficient base catalyzed alkylation reactions with aziridine electrophiles". supporting information; experimental part. p. 2474 - 2476. Retrieved 2009/02/03.