(S)-(R)-JOSIPHOS

Base Information

• Chemical Name: (S)-(R)-JOSIPHOS
• CAS No.: 162291-02-3
• Molecular Formula: C36H44 Fe P2
• Molecular Weight: 594.54
• Hs Code.: 29319090
• Mol file: 162291-02-3.mol

Synonyms:Ferrocene,1-[1-(dicyclohexylphosphino)ethyl]-2-(diphenylphosphino)-, [S-(R*,R*)]-;(S)-1-[(Rp)-[2-(Dicyclohexylphosphino)ferrocenyl]ethyl]diphenylphosphine

Chemical Property of (S)-(R)-JOSIPHOS

Chemical Property:

• PSA: 27.18000
• LogP: 9.12070
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

(S)-(+)-1-[(R)-2-(Diphenylphosphino)ferrocenyl]ethyldicyclohexylphosphine ethanol adduct, min. 97% (S)-(R)-JOSIPHOS ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-(R)-JOSIPHOS

There total 1 articles about (S)-(R)-JOSIPHOS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-N,N-dimethyl-1-[(R)-2-(diphenylphosphino)ferrocenyl]ethylamine + dicyclohexylphosphane (829-84-5) → (R)-1-[(Sp)-2-(diphenylphosphino)ferrocenyl]ethyldicyclohexylphosphine (162291-02-3)

Guidance literature:

With acetic acid; Inert atmosphere; Schlenk technique;

DOI:10.1002/chem.201902585

Reference yield: 88.0%

2-(Aminomethyl)pyridine (3731-51-9) + (R)-1-[(Sp)-2-(diphenylphosphino)ferrocenyl]ethyldicyclohexylphosphine (162291-02-3) + dichlorotris(triphenylphosphine)ruthenium(II) (15529-49-4,41756-81-4) → cis-RuCl2{(R)-(-)-1-[(S)-2-(diphenylphosphino)ferrocenyl]ethyldicyclohexylphosphine}[2-(H2NCH2)C5H4N]

Guidance literature:

(R)-1-[(S_p)-2-(diphenylphosphino)ferrocenyl]ethyldicyclohexylphosphine; dichlorotris(triphenylphosphine)ruthenium(II); In toluene; for 0.5h; Heating / reflux;

2-(Aminomethyl)pyridine; In toluene; at 20 - 110 ℃; for 4h; Heating / reflux;

Reference yield: 81.0%

(R)-1-[(Sp)-2-(diphenylphosphino)ferrocenyl]ethyldicyclohexylphosphine (162291-02-3) + bis[(2-methylene-6,6-dimethylbicyclo[3.1.1]hept-2,3,10-η(3)-enyl)palladium chloride] + silver trifluoromethanesulfonate (2923-28-6) → [(C5H5)Fe(C5H3(P(C6H5)2)CH(CH3)P(C6H11)2)]Pd(C10H15)(1+)*CF3SO3(1-)=[[(C5H5)Fe(C31H39P2)]Pd(C10H15)]OSO2CF3

Guidance literature:

In methanol; dichloromethane; stirring (10 h), Ag-salt soln. (MeOH) addn., stirring (dark, 1 h); filtering, distg., crystn. (CHCl3 / ether, -30°C, overnight), decanting, washing (ether), drying (vac.); elem. anal.;

DOI:10.1021/om00002a035

upstream raw materials:

dicyclohexylphosphane

Refernces