cyclopropane-1,1-dicarboxylic acid {3-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-ylamino]-phenyl}-amide (4-fluoro-phenyl)-amide

Base Information

• Chemical Name: cyclopropane-1,1-dicarboxylic acid {3-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-ylamino]-phenyl}-amide (4-fluoro-phenyl)-amide
• CAS No.: 849221-53-0
• Molecular Formula: C₃₄H₃₅FN₄O₆
• Molecular Weight: 614.674
• Mol file: 849221-53-0.mol

Synonyms:cyclopropane-1,1-dicarboxylic acid {3-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-ylamino]-phenyl}-amide (4-fluoro-phenyl)-amide

Chemical Property of cyclopropane-1,1-dicarboxylic acid {3-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-ylamino]-phenyl}-amide (4-fluoro-phenyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cyclopropane-1,1-dicarboxylic acid {3-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-ylamino]-phenyl}-amide (4-fluoro-phenyl)-amide

There total 10 articles about cyclopropane-1,1-dicarboxylic acid {3-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-ylamino]-phenyl}-amide (4-fluoro-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Fluoro-4-{[6-methoxy-7-(3-morpholinopropoxy)-4-quinolyl]oxy}-aniline (479690-10-3) + 1-((4-fluorophenyl)carbamoyl)cyclopropane-1-carbonyl chloride → cyclopropane-1,1-dicarboxylic acid {3-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-ylamino]-phenyl}-amide (4-fluoro-phenyl)-amide (849221-53-0)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; water; at 15 - 21 ℃; for 1h; Large scale;

Reference yield:

1-[2-amino-5-methoxy-4-(3-morpholin-4-yl-propoxy)-phenyl]-ethanone (1219937-97-9) → cyclopropane-1,1-dicarboxylic acid {3-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-ylamino]-phenyl}-amide (4-fluoro-phenyl)-amide (849221-53-0)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium ethanolate / methanol / 44 °C / Large scale

2: trichlorophosphate / acetonitrile / 50 - 82 °C / Large scale

3: sodium t-butanolate / N,N-dimethyl acetamide / 36 h / 95 - 100 °C

4: potassium carbonate / tetrahydrofuran; water / 1 h / 15 - 21 °C / Large scale

With sodium ethanolate; potassium carbonate; sodium t-butanolate; trichlorophosphate; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; water; acetonitrile;

Reference yield:

6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-ol, sodium salt (1167053-13-5,205448-38-0) → cyclopropane-1,1-dicarboxylic acid {3-fluoro-4-[6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinolin-4-ylamino]-phenyl}-amide (4-fluoro-phenyl)-amide (849221-53-0)

Guidance literature:

Multi-step reaction with 3 steps

1: trichlorophosphate / acetonitrile / 50 - 82 °C / Large scale

2: sodium t-butanolate / N,N-dimethyl acetamide / 36 h / 95 - 100 °C

3: potassium carbonate / tetrahydrofuran; water / 1 h / 15 - 21 °C / Large scale

With potassium carbonate; sodium t-butanolate; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl acetamide; water; acetonitrile;

upstream raw materials:

3-Fluoro-4-{[6-methoxy-7-(3-morpholinopropoxy)-4-quinolyl]oxy}-aniline

1-[5-methoxy-4-(3-bromo-propoxy)-2-nitro-phenyl]-ethanone

1-[5-methoxy-4-(3-morpholin-4-yl-propoxy)-2-nitro-phenyl]-ethanone

1-[2-amino-5-methoxy-4-(3-morpholin-4-yl-propoxy)-phenyl]-ethanone

Refernces