N-benzyl-3-aza<3.3.0>bicyclooctane

Base Information

• Chemical Name: N-benzyl-3-aza<3.3.0>bicyclooctane
• CAS No.: 118989-10-9
• Molecular Formula: C₁₄H₁₉N
• Molecular Weight: 201.312
• Mol file: 118989-10-9.mol

Synonyms:N-benzyl-3-aza<3.3.0>bicyclooctane

Chemical Property of N-benzyl-3-aza<3.3.0>bicyclooctane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-benzyl-3-aza<3.3.0>bicyclooctane

There total 8 articles about N-benzyl-3-aza<3.3.0>bicyclooctane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-benzyl-7,7-dichloro-3-azabicyclo<3.3.0>octane → N-benzyl-3-aza<3.3.0>bicyclooctane (118989-10-9)

Guidance literature:

With tetrabutylammomium bromide; tetra-(n-butyl)ammonium iodide; In acetonitrile; electrochemical reduction;

DOI:10.1080/00397919508015487

Reference yield:

octahydrocyclopenta[c]pyrrole (1468-87-7,5661-03-0,10268-00-5) + benzyl bromide (100-39-0) → N-benzyl-3-aza<3.3.0>bicyclooctane (118989-10-9)

Guidance literature:

With potassium carbonate; In dichloromethane; at 35 ℃; for 20h; Inert atmosphere;

DOI:10.1002/cjoc.201900360

Reference yield:

2-Benzyl-2-(1-hydroxymethyl-propyl)-octahydro-cyclopenta[c]pyrrolium; bromide → N-benzyl-3-aza<3.3.0>bicyclooctane (118989-10-9)

Guidance literature:

With potassium tert-butylate; In tert-butyl alcohol; Yield given; Heating;

DOI:10.1016/S0040-4020(01)87128-3

upstream raw materials:

N-(1'-hydroxy-2'-butyl)-3-aza-3,3,0-bicyclooctane

benzyl chloride

N-(1'-tert-butoxy-2'-butyl)-3-aza<3,3,0>bicyclooctane

benzyl bromide

Downstream raw materials:

octahydrocyclopenta[c]pyrrole

Refernces

• 1、 Tan, Wei,Wang, Cuihong,Jiang, Xuefeng. "Visible-Light-Mediated C(sp3)–H Thiocarbonylation for Thiolactam Preparation with Potassium Sulfide". supporting information. p. 1234 - 1238. Retrieved 2019/11/21.
• 2、 Roussi, Georges,Zhang, Jidong. "A 3+2 CYCLOADDITION ROUTE TO N-H PYRROLIDINES DEVOID OF ELECTRON-WITHDRAWING GROUPS". . p. 3481 - 3482. Retrieved 2007/10/02.